gene

NR3C1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR3C1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

611Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

NR3C1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, interacts with, regulates. Associated with ALS, Als, Alzheimer. Connected to 195 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NR3C1
Aliases	Glucocorticoid receptor, GR, GCR
Chromosome	5q31.3
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	Selective glucocorticoid receptor modulators (SRMs) or antagonists
Mechanism of Action	Selective glucocorticoid receptor modulators (SRMs) or antagonists
Druggability	Medium (0.53)
Clinical Stage	Approved
Molecular Weight	86 kDa
Amino Acids	777 aa
Pathways	HPA axis, NF-kB suppression, MAPK signaling, Circadian rhythm
UniProt ID	F1D8N4
GeneCards	NR3C1
Human Protein Atlas	NR3C1
Associated Diseases	Addiction, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Corticosterone, Dazucorilant, dexamethasone, Melatonin
Interactions	ABCA1, ABCB1, ACAT1, ALZHEIMER, AND, ANXIETY
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	611 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — NR3C1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1M2Z — X-ray / Cryo-EM

🔮 AI Predicted Structure

F1D8N4 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    NR3C1["NR3C1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    NR3C1["NR3C1"] -->|"interacts"| CRH["CRH"]
    NR3C1["NR3C1"] -->|"interacts"| TNFA["TNFA"]
    NR3C1["NR3C1"] -->|"co discussed"| DRD2["DRD2"]
    NR3C1["NR3C1"] -->|"co discussed"| CHR2["CHR2"]
    NR3C1["NR3C1"] -->|"co discussed"| CLOCK["CLOCK"]
    CRH_1["CRH"] -->|"interacts"| NR3C1["NR3C1"]
    TNFA_2["TNFA"] -->|"interacts"| NR3C1["NR3C1"]
    FOXP3["FOXP3"] -->|"co discussed"| NR3C1["NR3C1"]
    TNFA_3["TNFA"] -->|"co discussed"| NR3C1["NR3C1"]
    style NR3C1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (405)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NR3C1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
HPA axis	involved_in	pathway	0.95
Hypothalamic-Pituitary-Adrenal Axis	regulates	pathway	0.85
Alzheimer's Disease	associated_with	disease	0.85
emotional aspects of tinnitus	mediates	phenotype	0.85
stress response	mediates	process	0.80
Cognitive Function	involved_in	phenotype	0.80
HPA_axis	regulates	pathway	0.80
Alzheimer'S Disease	associated_with	disease	0.75
Hypothalamic-Pituitary-Adrenal Axis	involved_in	pathway	0.75
Hypersexual Disorder	biomarker_for	disease	0.70
Alzheimer's disease	biomarker_for	disease	0.70
Hypersexual Disorder	associated_with	disease	0.70
Melatonin	involved_in	drug	0.70
NF-kB signaling	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
cortex	expressed_in	brain_region	0.70
epigenetic regulation	participates_in	pathway	0.70
Ms	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	expressed_in	disease	0.65
Depression	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Anxiety	inhibits	disease	0.65
Cancer	activates	disease	0.65
Ms	inhibits	disease	0.65
Als	regulates	disease	0.65
ALS	associated_with	disease	0.65
Depression	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Als	activates	disease	0.65
Ms	expressed_in	disease	0.65
Hypertension	associated_with	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Ptsd	inhibits	disease	0.65
Carcinoma	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Diabetes	associated_with	disease	0.65
Multiple Sclerosis	interacts_with	disease	0.65
Myasthenia Gravis	interacts_with	disease	0.65
Addiction	associated_with	disease	0.65
Ptsd	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Depression	activates	disease	0.65

Incoming (206)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NR3C1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
Dazucorilant	targets	drug	0.90
Haloperidol	upregulates	drug	0.90
h-1e564178	targets	hypothesis	0.90
Corticosterone	binds	compound	0.85
miR-137-3p	regulates	biomarker	0.85
FKBP5	associated_with	gene	0.80
CRH	associated_with	gene	0.80
Melatonin	targets	drug	0.80
DNA	associated_with	gene	0.70
dexamethasone	regulates	compound	0.70
CRH	interacts_with	gene	0.61
TNFA	interacts_with	gene	0.61
BDNF	associated_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
DEPRESSION	inhibits	gene	0.60
SKA2	associated_with	gene	0.60
ANXIETY	inhibits	gene	0.60
CRHBP	interacts_with	gene	0.60
FKBP5	interacts_with	gene	0.60
CRHR1	interacts_with	gene	0.60
MIRNAS	inhibits	gene	0.60
IL-18	associated_with	gene	0.60
CANCER	regulates	gene	0.60
MIRNAS	associated_with	gene	0.60
DNA	interacts_with	gene	0.60
apoptosis	inhibits	pathway	0.60
RNA	inhibits	gene	0.60
GENES	interacts_with	gene	0.60
DEPRESSION	regulates	gene	0.60
RNA	regulates	gene	0.60
NR3C2	activates	gene	0.60
AND	associated_with	gene	0.60
DEPRESSION	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
HSA-MIR-181A-5P	associated_with	gene	0.60
MYC	associated_with	gene	0.60
NFKB1	associated_with	gene	0.60
BDNF	interacts_with	gene	0.60
ACAT1	activates	gene	0.60
LRP1	associated_with	gene	0.60
MAPK1	targets	gene	0.60
NATURAL COMPOUNDS	associated_with	gene	0.60
TNF-ALPHA	associated_with	gene	0.60
ITGB1	associated_with	gene	0.60
BACE1	targets	gene	0.60
HPA AXIS RELATED GENES	associated_with	gene	0.60
AND	expressed_in	gene	0.60
GSK3B	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning NR3C1 in their description or question text

No additional research found