gene

NR3C1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR3C1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

611Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

NR3C1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, interacts with, regulates. Associated with ALS, Als, Alzheimer. Connected to 195 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NR3C1
Aliases	Glucocorticoid receptor, GR, GCR
Chromosome	5q31.3
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	Selective glucocorticoid receptor modulators (SRMs) or antagonists
Mechanism of Action	Selective glucocorticoid receptor modulators (SRMs) or antagonists
Druggability	Medium (0.53)
Clinical Stage	Approved
Molecular Weight	86 kDa
Amino Acids	777 aa
Pathways	HPA axis, NF-kB suppression, MAPK signaling, Circadian rhythm
UniProt ID	F1D8N4
GeneCards	NR3C1
Human Protein Atlas	NR3C1
Associated Diseases	Addiction, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Corticosterone, Dazucorilant, dexamethasone, Melatonin
Interactions	ABCA1, ABCB1, ACAT1, ALZHEIMER, AND, ANXIETY
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	611 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — NR3C1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1M2Z — X-ray / Cryo-EM

🔮 AI Predicted Structure

F1D8N4 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    NR3C1["NR3C1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    NR3C1["NR3C1"] -->|"interacts"| CRH["CRH"]
    NR3C1["NR3C1"] -->|"interacts"| TNFA["TNFA"]
    NR3C1["NR3C1"] -->|"co discussed"| DRD2["DRD2"]
    NR3C1["NR3C1"] -->|"co discussed"| CHR2["CHR2"]
    NR3C1["NR3C1"] -->|"co discussed"| CLOCK["CLOCK"]
    CRH_1["CRH"] -->|"interacts"| NR3C1["NR3C1"]
    TNFA_2["TNFA"] -->|"interacts"| NR3C1["NR3C1"]
    FOXP3["FOXP3"] -->|"co discussed"| NR3C1["NR3C1"]
    TNFA_3["TNFA"] -->|"co discussed"| NR3C1["NR3C1"]
    style NR3C1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (405)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NR3C1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
HPA axis	involved_in	pathway	0.95
emotional aspects of tinnitus	mediates	phenotype	0.85
Hypothalamic-Pituitary-Adrenal Axis	regulates	pathway	0.85
Alzheimer's Disease	associated_with	disease	0.85
stress response	mediates	process	0.80
Cognitive Function	involved_in	phenotype	0.80
HPA_axis	regulates	pathway	0.80
Alzheimer'S Disease	associated_with	disease	0.75
Hypothalamic-Pituitary-Adrenal Axis	involved_in	pathway	0.75
Hypersexual Disorder	biomarker_for	disease	0.70
cortex	expressed_in	brain_region	0.70
Hypersexual Disorder	associated_with	disease	0.70
Melatonin	involved_in	drug	0.70
Alzheimer's disease	biomarker_for	disease	0.70
oxidative stress response	participates_in	pathway	0.70
epigenetic regulation	participates_in	pathway	0.70
NF-kB signaling	participates_in	pathway	0.70
Als	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Ms	interacts_with	disease	0.65
Multiple Sclerosis	interacts_with	disease	0.65
Ptsd	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Neuroinflammation	regulates	disease	0.65
Anxiety	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
ALS	regulates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Ptsd	inhibits	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Myasthenia Gravis	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Depression	activates	disease	0.65
Diabetes	associated_with	disease	0.65
Als	regulates	disease	0.65
Als	activates	disease	0.65
ALS	expressed_in	disease	0.65

Incoming (206)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NR3C1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
Dazucorilant	targets	drug	0.90
Haloperidol	upregulates	drug	0.90
h-1e564178	targets	hypothesis	0.90
miR-137-3p	regulates	biomarker	0.85
Corticosterone	binds	compound	0.85
CRH	associated_with	gene	0.80
FKBP5	associated_with	gene	0.80
Melatonin	targets	drug	0.80
DNA	associated_with	gene	0.70
dexamethasone	regulates	compound	0.70
TNFA	interacts_with	gene	0.61
CRH	interacts_with	gene	0.61
BDNF	associated_with	gene	0.60
ESR1	expressed_in	gene	0.60
CALCA	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
CASP3	interacts_with	gene	0.60
FKBP5	activates	gene	0.60
PVALB	interacts_with	gene	0.60
EGR1	protects_against	gene	0.60
ATF3	protects_against	gene	0.60
BANG	regulates	gene	0.60
PPARG	protects_against	gene	0.60
dexamethasone	interacts_with	compound	0.60
TNF-ALPHA	associated_with	gene	0.60
TNF	associated_with	gene	0.60
JUN	associated_with	gene	0.60
TNF	expressed_in	gene	0.60
ESR2	expressed_in	gene	0.60
JUN	activates	gene	0.60
ESR1	treats	gene	0.60
NFE2L2	inhibits	gene	0.60
dexamethasone	inhibits	compound	0.60
NFE2L2	regulates	gene	0.60
GR	regulates	gene	0.60
GR	associated_with	gene	0.60
IL8	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
AND	protects_against	gene	0.60
MICRORNAS	protects_against	gene	0.60
SKA2	associated_with	gene	0.60
ITGB1	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
IL-18	associated_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
TAU	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning NR3C1 in their description or question text

No additional research found