gene

RAD51

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAD51: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

69Connections

0Hypotheses

0Analyses

29Outgoing

40Incoming

0Experiments

0Debates

Summary

RAD51 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Als, Ataxia, Cancer. Connected to 36 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAD51
Full Name	RAD51 Recombinase
Chromosome	15q15.1
Function	RAD51 is a recombinase protein essential for homologous recombination (HR) repair of double-strand DNA breaks.
Primary Expression	all brain regions, with particularly high expression in dopaminergic neurons of the substantia nigra, motor cortex, and hippo
Molecular Weight	37 kDa
Amino Acids	339 aa
Pathways	Homologous Recombination
UniProt ID	P43251
NCBI Gene ID	5888
Ensembl ID	ENSG00000102009
OMIM	179520
GeneCards	RAD51
Human Protein Atlas	RAD51
Associated Diseases	neurodegeneration
Interactions	AND, ATM, ATR, BRCA1, CANCER, DNA
KG Connections	69 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAD51 — AlphaFold P43251 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAD51

gene · 511 words

→

RAD51 Protein

protein · 687 words

→

Pathway Diagram

graph TD
    RAD51["RAD51"]
    Als{"Als"}
    RAD51 -->|"activates"| Als
    Ms{"Ms"}
    RAD51 -->|"activates"| Ms
    Cancer{"Cancer"}
    RAD51 -->|"activates"| Cancer
    Tumor{"Tumor"}
    RAD51 -->|"activates"| Tumor
    RAD51 -->|"regulates"| Cancer
    Ataxia{"Ataxia"}
    RAD51 -->|"regulates"| Ataxia
    ATR["ATR"]
    RAD51 -->|"activates"| ATR
    ATM["ATM"]
    RAD51 -->|"activates"| ATM
    RAD54["RAD54"]
    RAD51 -->|"activates"| RAD54
    VCP["VCP"]
    RAD51 -->|"activates"| VCP
    Ferroptosis(["Ferroptosis"])
    RAD51 -->|"activates"| Ferroptosis
    NF1["NF1"]
    RAD51 -->|"regulates"| NF1
    RAD54 -->|"activates"| RAD51
    VCP -->|"activates"| RAD51
    ATM -->|"activates"| RAD51
    DNA["DNA"]
    DNA -->|"activates"| RAD51
    ATR -->|"activates"| RAD51
    P53["P53"]
    P53 -->|"activates"| RAD51
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"activates"| RAD51
    CANCER["CANCER"]
    CANCER -->|"activates"| RAD51
    BRCA1["BRCA1"]
    BRCA1 -->|"activates"| RAD51
    ATM -->|"regulates"| RAD51
    TP53["TP53"]
    TP53 -->|"regulates"| RAD51
    NBN["NBN"]
    NBN -->|"regulates"| RAD51
    style RAD51 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
Homologous Recombination	involved_in	process	0.95
Cancer	regulates	disease	0.65
Ataxia	regulates	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
AND	activates	gene	0.60
ATM	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
Ferroptosis	activates	pathway	0.60
MCM8	activates	gene	0.60
Ubiquitin	activates	protein	0.60
ATR	activates	gene	0.60
RAD54	degrades	entity	0.60
RAD54	activates	gene	0.60
VCP	activates	gene	0.60
RFWD3	targets	gene	0.60
RFWD3	associated_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
RFWD3	activates	gene	0.60
DNA	activates	gene	0.60
NF1	regulates	gene	0.60
BRCA2	regulates	gene	0.60
DNA DAMAGE	activates	concept	0.50
HOMOLOGOUS RECOMBINATION	activates	concept	0.50
DNA DAMAGE	inhibits	concept	0.50
RAD54	co_expressed_with	gene	0.50
VCP	co_expressed_with	gene	0.50

Incoming (40)

Source	Relation	Type	Str
genes-rad51	linked_to	wiki_page	1.00
RFWD3	catalyzes	gene	0.90
UBIQUITIN	mediates	entity	0.90
DNA double-strand breaks	activates	process	0.90
Dna Double-Strand Breaks	activates	mechanism	0.90
RFWD3	ubiquitinates	gene	0.90
VCP	degrades	protein	0.85
VCP	activates	gene	0.60
ATM	activates	gene	0.60
ATR	activates	gene	0.60
ATM	inhibits	gene	0.60
IR	inhibits	gene	0.60
NBS1	inhibits	gene	0.60
RAD54	activates	gene	0.60
PARP1	inhibits	gene	0.60
RFWD3	activates	gene	0.60
TP53	regulates	gene	0.60
NBN	regulates	gene	0.60
BRIP1	regulates	gene	0.60
STK11	regulates	gene	0.60
CHEK2	regulates	gene	0.60
PTEN	regulates	gene	0.60
BRCA1	regulates	gene	0.60
PALB2	regulates	gene	0.60
ATM	regulates	gene	0.60
RAD18	interacts_with	gene	0.60
CANCER	regulates	gene	0.60
CDH1	regulates	gene	0.60
BRCA1	activates	gene	0.60
DNA	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
MCM8	activates	gene	0.60
CANCER	activates	gene	0.60
DNA	inhibits	gene	0.60
P53	activates	gene	0.60
LATE	inhibits	entity	0.60
DNA	interacts_with	gene	0.60
late	inhibits	disease	0.50
ATR	co_expressed_with	gene	0.50
ATM	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAD51 in their description or question text

No additional research found