gene

adnp

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adnp: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

106Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ADNP
Protein Type	Transcription Factor
Function	ADNP encodes a 1,102 amino acid protein containing a homeobox domain, nine zinc fingers, and a PxVxL motif that mediates interaction with the SWI/SNF chromatin remodeling complex through HP1.
Molecular Weight	124 kDa
Amino Acids	102 aa
Pathways	Autophagy, Epigenetic, Wnt
Ensembl ID	ENSG00000101126
GeneCards	ADNP
Human Protein Atlas	ADNP
Associated Diseases	Ms, Aging
Interactions	ALZHEIMER, P2X7, P2X7 RECEPTOR
KG Connections	21 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ADNP Gene

gene · 916 words

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Pathway Diagram

flowchart TD
    N0["adnp"]
    N1["SYNAPSE"]
    N0 -->|"regulates"| N1
    N2["Neuroprotection"]
    N0 -->|"regulates"| N2
    N0 -->|"expressed in"| N1
    N3["GENE EXPRESSION"]
    N0 -->|"expressed in"| N3
    N4["ALZHEIMER"]
    N0 -->|"activates"| N4
    N5["Alzheimer'S Disease"]
    N0 -->|"activates"| N5
    N6["disease"]
    N0 -->|"activates"| N6
    N7["ALZHEIMER'S"]
    N0 -->|"activates"| N7
    N8["Astrocytes"]
    N0 -->|"inhibits"| N8
    N9["Astrocyte"]
    N0 -->|"inhibits"| N9
    N10["APP/PS1"]
    N0 -->|"inhibits"| N10
    N0 -->|"expressed in"| N8
    N0 -->|"expressed in"| N9
    N11["P2X7 RECEPTOR"]
    N0 -->|"inhibits"| N11

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N4 gene
    class N5 disease
    class N6 disease
    class N11 protein

Outgoing (83)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ADNP	data_in	dataset_row	0.00
Autophagy	interacts_with	pathway	0.70
AUTOPHAGY	interacts_with	gene	0.70
Aging	causes	disease	0.65
Autism	expressed_in	disease	0.65
Als	activates	disease	0.65
Aging	protects_against	disease	0.65
Alzheimer	activates	disease	0.65
Autism	protects_against	disease	0.65
Cardiac	expressed_in	disease	0.65
Schizophrenia	activates	disease	0.65
Ms	associated_with	disease	0.65
ALS	activates	disease	0.65
Autism	therapeutic_target	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Tauopathy	interacts_with	disease	0.65
P21	inhibits	gene	0.60
AXON	inhibits	gene	0.60
Neuron	inhibits	cell_type	0.60
TAUOPATHY	interacts_with	gene	0.60
Astrocyte	inhibits	cell_type	0.60
ALZHEIMER	inhibits	gene	0.60
APP/PS1	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
SNAP25	expressed_in	gene	0.60
LC3	associated_with	gene	0.60
schizophrenia	activates	disease	0.60
APP	protects_against	gene	0.60
MAPT	expressed_in	gene	0.60
NLGN1	expressed_in	gene	0.60
NLGN2	expressed_in	gene	0.60
PAX6	expressed_in	gene	0.60
SMARCA4	expressed_in	gene	0.60
BECN1	associated_with	gene	0.60
SIRT1	interacts_with	gene	0.60
P2X7	inhibits	gene	0.60
HDAC2	associated_with	gene	0.60
YY1	associated_with	gene	0.60
SNF	interacts_with	gene	0.60
SWI	interacts_with	gene	0.60
Wnt	expressed_in	pathway	0.60
WNT	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
Fibroblast	associated_with	cell_type	0.60
App	inhibits	protein	0.60
autism spectrum disorder	protects_against	disease	0.60
Alzheimer's disease	activates	disease	0.60
PS1	protects_against	gene	0.60
autism spectrum disorder	interacts_with	disease	0.60

Incoming (23)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ADNP	data_in	dataset_row	0.00
ALZHEIMER	activates	gene	0.60
SIRT1	interacts_with	gene	0.60
YY1	associated_with	gene	0.60
HDAC2	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
SYNAPSE	regulates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ASTROCYTE	inhibits	gene	0.60
P21	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AXON	inhibits	gene	0.60
AND	inhibits	gene	0.60
APP/PS1	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
P2X7	inhibits	gene	0.60
APP	inhibits	gene	0.60
AUTISM	regulates	disease	0.50
AUTISM	protects_against	disease	0.50
SCHIZOPHRENIA	activates	disease	0.50
AUTISM	inhibits	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning adnp in their description or question text

No additional research found