gene

MPV17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MPV17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

7Outgoing

26Incoming

0Experiments

0Debates

Summary

MPV17 Gene - MPV17 Mitochondrial Inner Membrane Protein

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🧬 Gene Info

Gene Symbol	MPV17
Protein Type	Protein
Function	MPV17 is a mitochondrial inner membrane protein involved in mitochondrial DNA maintenance.
Molecular Weight	~20 kDa
Amino Acids	176 aa
UniProt ID	Search UniProt
GeneCards	MPV17
Human Protein Atlas	MPV17
Multiple transmembrane helices	MPV17 contains three predicted transmembrane helices that anchor it in the mitochondrial inner membrane
N-terminal matrix-facing domain	Contains functional motifs important for protein interactions
Homomeric assembly	Forms higher-order complexes in the inner membrane
Associated Diseases	neurodegeneration
KG Connections	33 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MPV17 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MPV17 Gene - MPV17 Mitochondrial Inner Membrane Protein

gene · 1918 words

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MPV17 Protein

protein · 634 words

→

Pathway Diagram

graph TD
    MPV17["MPV17"]
    POLG["POLG"]
    RRM2B["RRM2B"]
    TK2["TK2"]
    DGUOK["DGUOK"]
    SUCLA2["SUCLA2"]
    TFAM["TFAM"]
    MtDNA["Mitochondrial DNA"]
    MtDysfunc["Mitochondrial Dysfunction"]
    DNADepl["mtDNA Depletion"]
    ALS["ALS"]
    Neuropathy["Peripheral Neuropathy"]
    MitBiog["Mitochondrial Biogenesis"]
    ETC["Electron Transport Chain"]
    Apoptosis["Neuronal Apoptosis"]

    MPV17 -->|"regulates"| MtDNA
    MPV17 -->|"maintains"| MitBiog
    POLG -->|"replicates"| MtDNA
    RRM2B -->|"provides dNTPs for"| MtDNA
    TK2 -->|"phosphorylates dNTPs for"| MtDNA
    DGUOK -->|"salvages dNTPs for"| MtDNA
    SUCLA2 -->|"provides dNTPs for"| MtDNA
    TFAM -->|"packages"| MtDNA
    MtDNA -->|"encodes components of"| ETC
    MPV17 -->|"dysfunction leads to"| DNADepl
    DNADepl -->|"causes"| MtDysfunc
    MtDysfunc -->|"impairs"| ETC
    ETC -->|"dysfunction triggers"| Apoptosis
    MtDysfunc -->|"manifests as"| ALS
    MtDysfunc -->|"manifests as"| Neuropathy

    style MPV17 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style TFAM fill:#4a1a6b
    style MitBiog fill:#1b5e20
    style DNADepl fill:#ef5350
    style MtDysfunc fill:#ef5350
    style Apoptosis fill:#ef5350
    style ALS fill:#7d4200
    style Neuropathy fill:#7d4200
    style POLG fill:#4a1a6b
    style RRM2B fill:#4a1a6b
    style TK2 fill:#4a1a6b
    style DGUOK fill:#4a1a6b
    style SUCLA2 fill:#4a1a6b

Outgoing (7)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Neuropathy	expressed_in	disease	0.65
SUCLA2	expressed_in	gene	0.60
RRM2B	expressed_in	gene	0.60
POLG	contributes_to	gene	0.60
DGUOK	associated_with	gene	0.60
DNA	expressed_in	gene	0.60

Incoming (26)

Source	Relation	Type	Str
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
MITOCHONDRIAL DNA	expressed_in	gene	0.60
MTDNA	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
AND	associated_with	gene	0.60
POLG2	associated_with	gene	0.60
SLC25A4	associated_with	gene	0.60
MFN2	associated_with	gene	0.60
TYMP	associated_with	gene	0.60
RRM2B	associated_with	gene	0.60
TK2	associated_with	gene	0.60
SUCLA2	associated_with	gene	0.60
SUCLG1	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
POLG	associated_with	gene	0.60
RNASEH1	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
TWNK	associated_with	gene	0.60
DGUOK	contributes_to	gene	0.60
SUCLG1	expressed_in	gene	0.60
TK2	expressed_in	gene	0.60
TYMP	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MPV17 in their description or question text

No additional research found