Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DGUOK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Mitochondrial deoxyguanosine kinase involved in mtDNA maintenance and nucleotide salvage pathway
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| Gene Symbol | DGUOK |
| Full Name | Deoxyguanosine Kinase |
| Chromosome | 2p13.1 |
| Protein Family | Deoxyguanosine kinase family |
| Protein Type | Enzyme |
| Function | is a nuclear-encoded gene that encodes a crucial mitochondrial enzyme involved in the nucleotide salvage pathway. |
| Primary Expression | all human tissues with particularly high expression in liver, kidney, and brain |
| Subcellular Localization | the mitochondrial matrix. Each subunit contains an N-terminal mitochondrial targeting peptide (approximately 30 amino ac |
| Molecular Weight | 34 kDa |
| Amino Acids | 278 aa |
| Exons | 7 |
| UniProt ID | [Q01459](https://www.uniprot.org/uniprot/Q01459) |
| Ensembl ID | ENSG00000198246 |
| OMIM | 601465 |
| GeneCards | DGUOK |
| Human Protein Atlas | DGUOK |
| Associated Diseases | neurodegeneration |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DGUOK["DGUOK
Deoxyguanosine Kinase"]
%% Mitochondrial DNA maintenance pathway
POLG["POLG
DNA Polymerase Gamma"]
TK2["TK2
Thymidine Kinase 2"]
RRM2B["RRM2B
Ribonucleotide Reductase"]
TFAM["TFAM
Transcription Factor A"]
%% Mitochondrial dynamics and structure
MFN2["MFN2
Mitofusin 2"]
OPA1["OPA1
Optic Atrophy 1"]
%% Nucleotide transport
SLC25A4["SLC25A4
Adenine Nucleotide Translocator"]
%% Mitochondrial energy metabolism
SUCLA2["SUCLA2
Succinate-CoA Ligase Alpha"]
SUCLG1["SUCLG1
Succinate-CoA Ligase Beta"]
%% Central processes
mtDNA_POOL["Mitochondrial dNTP Pool"]
mtDNA_REP["Mitochondrial DNA Replication"]
MITO_FUNC["Mitochondrial Function"]
%% Pathological outcomes
ALS["Amyotrophic Lateral Sclerosis"]
NEUROPATHY["Peripheral Neuropathy"]
%% Core pathway connections
DGUOK -->|"phosphorylates"| mtDNA_POOL
TK2 -->|"phosphorylates"| mtDNA_POOL
RRM2B -->|"provides substrates"| mtDNA_POOL
mtDNA_POOL -->|"supplies nucleotides"| mtDNA_REP
POLG -->|"replicates"| mtDNA_REP
TFAM -->|"regulates"| mtDNA_REP
mtDNA_REP -->|"maintains"| MITO_FUNC
%% Energy metabolism
SUCLA2 -->|"ATP synthesis"| MITO_FUNC
SUCLG1 -->|"ATP synthesis"| MITO_FUNC
%% Mitochondrial dynamics
MFN2 -->|"fusion"| MITO_FUNC
OPA1 -->|"cristae structure"| MITO_FUNC
SLC25A4 -->|"nucleotide transport"| MITO_FUNC
%% Pathological outcomes
MITO_FUNC -->|"dysfunction leads to"| ALS
MITO_FUNC -->|"dysfunction leads to"| NEUROPATHY
%% Styling
style DGUOK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
style mtDNA_POOL fill:#1b5e20,stroke:#4caf50,stroke-width:2px
style mtDNA_REP fill:#1b5e20,stroke:#4caf50,stroke-width:2px
style MITO_FUNC fill:#1b5e20,stroke:#4caf50,stroke-width:2px
style POLG fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style TK2 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style RRM2B fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style TFAM fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style ALS fill:#7d4200,stroke:#ff9800,stroke-width:2px
style NEUROPATHY fill:#7d4200,stroke:#ff9800,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Neuropathy | expressed_in | disease | 0.65 |
| GENES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| SUCLG1 | associated_with | gene | 0.60 |
| TK2 | associated_with | gene | 0.60 |
| TYMP | associated_with | gene | 0.60 |
| MPV17 | contributes_to | gene | 0.60 |
| SUCLA2 | associated_with | gene | 0.60 |
| RRM2B | associated_with | gene | 0.60 |
| POLG | contributes_to | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GENES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | expressed_in | gene | 0.60 |
| POLG2 | associated_with | gene | 0.60 |
| SLC25A4 | associated_with | gene | 0.60 |
| MFN2 | associated_with | gene | 0.60 |
| TYMP | associated_with | gene | 0.60 |
| RRM2B | associated_with | gene | 0.60 |
| TK2 | associated_with | gene | 0.60 |
| SUCLA2 | associated_with | gene | 0.60 |
| SUCLG1 | associated_with | gene | 0.60 |
| TFAM | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| RNASEH1 | associated_with | gene | 0.60 |
| OPA1 | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| MPV17 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DGUOK in their description or question text
No additional research found