| Gene Symbol | RIPK3 |
| Function | Necrosome formation: RHIM-RHIM interactions recruit RIPK3 to activated RIPK1; RIPK1 undergoes conformational change exposing its RHIM |
| Primary Expression | Restrictive — immune cells, neurons, some epithelial cells |
| Molecular Weight | 56.8 kDa (527 amino acids) |
| Amino Acids | 527 aa |
| Pathways | Apoptosis, Autophagy, Dna Methylation, Ferroptosis, Immune Response |
| GeneCards | RIPK3 |
| Human Protein Atlas | RIPK3 |
| Associated Diseases | AD, ALI, Als, Alzheimer |
| Known Drugs/Compounds | Adeno-Associated Virus, HSYA, metformin, Mitochondrial ROS, Ponicidin, rapamycin |
| Interactions | ABCD3, ACOD1, ACSL4, Actin, AD, ADAR1 |
| KG Connections | 1530 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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