concept

REACTIVE OXYGEN SPECIES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REACTIVE OXYGEN SPECIES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

521Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	REACTIVE OXYGEN SPECIES
Key Genes/Proteins	ABCD3, ACTIN, ALZHEIMER DISEASE, AMBRA1, AMPK, ATG
Related Diseases	ALS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Reactive Oxygen Species (ROS) Pathway

mechanism · 3211 words

→

Pathway Diagram

graph TD
    REACTIVE_OXYGEN_SPECIES["REACTIVE OXYGEN SPECIES"]
    REACTIVE_OXYGEN_SPECIES -->|"modulates"| DUBS["DUBS"]
    REACTIVE_OXYGEN_SPECIES -->|"modulates"| DUB["DUB"]
    REACTIVE_OXYGEN_SPECIES -->|"involved_in"| Neutrophil_Extracellular_Traps["Neutrophil Extracellular Traps"]
    REACTIVE_OXYGEN_SPECIES -.biomarker for.-> Hypertrophic_Scar["Hypertrophic Scar"]
    REACTIVE_OXYGEN_SPECIES -->|"modulates"| Catalytic_Cysteine["Catalytic Cysteine"]
    REACTIVE_OXYGEN_SPECIES -->|"contributes to"| amyloid_beta["amyloid beta"]
    REACTIVE_OXYGEN_SPECIES -->|"activates"| Separating_Microneedles["Separating Microneedles"]
    REACTIVE_OXYGEN_SPECIES -->|"contributes to"| Learning_and_Memory_Deficits["Learning and Memory Deficits"]
    REACTIVE_OXYGEN_SPECIES -->|"contributes to"| Protein_Accumulation["Protein Accumulation"]
    REACTIVE_OXYGEN_SPECIES -->|"activates"| mitochondrial_dysfunction["mitochondrial dysfunction"]
    HSPA1A["HSPA1A"] -->|"inhibits"| REACTIVE_OXYGEN_SPECIES
    Antioxidants["Antioxidants"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    PGC1A["PGC1A"] -->|"regulates"| REACTIVE_OXYGEN_SPECIES
    SLC7A11["SLC7A11"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    MT1["MT1"] -->|"modulates"| REACTIVE_OXYGEN_SPECIES
    MT2["MT2"] -->|"modulates"| REACTIVE_OXYGEN_SPECIES
    Dolutegravir["Dolutegravir"] -->|"upregulates"| REACTIVE_OXYGEN_SPECIES
    Lactic_Acid["Lactic Acid"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    GJA1_20k["GJA1-20k"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    Mitophagic_Flux_Inhibition["Mitophagic Flux Inhibition"] -->|"causes"| REACTIVE_OXYGEN_SPECIES

Outgoing (71)

Target	Relation	Type	Str
Alzheimer's Disease	contributes_to	disease	0.95
Neurodegeneration	causes	process	0.95
Parkinson Disease	contributes_to	disease	0.95
Acute Kidney Injury	associated_with	disease	0.90
Neurodegeneration	contributes_to	process	0.90
DNM1L	phosphorylates	protein	0.90
PANoptosis	activates	process	0.90
AMPK-mTOR Pathway	activates	pathway	0.90
GSDME	cleaves	protein	0.88
Oxidative Stress	causes	process	0.88
Hypertrophic Scar	drives	disease	0.85
Amyloid Beta Aggregation	upregulates	process	0.85
Mitochondrial Impairment	causes	phenotype	0.85
glioblastoma	treats	disease	0.85
TFEB Nuclear Translocation	mediates	mechanism	0.85
cytoskeletal proteins	degrades	protein	0.85
chondrocytes	associated_with	cell_type	0.85
ZBP1	activates	protein	0.85
Diabetes-Associated Cognitive Impairment	contributes_to	disease	0.80
proinflammatory cytokines	increases	compound	0.80
Senescence	contributes_to	process	0.80
cognitive deficits	causes	phenotype	0.80
P53	upstream_of	gene	0.80
amyloid beta	contributes_to	protein	0.80
Stimuli-responsive nanoplatforms	associated_with	compound	0.75
oxidative stress	activates	process	0.70
mitochondrial dysfunction	activates	process	0.70
brain damage	causes	process	0.70
Brain cell death	activates	process	0.70
mitochondrial fragmentation	activates	process	0.70
Oxidative stress	causes	process	0.70
neuroapoptosis	activates	process	0.70
neuronal damage	activates	process	0.70
Mitochondrial dysfunction	activates	process	0.70
oxidative damage	activates	process	0.70
Oxidative stress	activates	process	0.70
BBB disruption	activates	process	0.70
CELL PROLIFERATION	associated_with	concept	0.50
MONOCYTE	activates	concept	0.50
NUCLEUS	regulates	concept	0.50
Proteins	regulates	protein	0.50
Cognitive Decline	causes	disease	0.50
DENDRITIC CELLS	interacts_with	concept	0.50
HEPATOCYTES	interacts_with	concept	0.50
MONOCYTES	interacts_with	concept	0.50
NEUROFIBRILLARY TANGLES	activates	concept	0.50
Proteins	activates	protein	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
Cellular Senescence	activates	cell_type	0.50
Proteins	causes	protein	0.50

Incoming (450)

Source	Relation	Type	Str
DTG	upregulates	entity	0.95
Ferroptosis	causes	process	0.95
Celastrol	promotes	compound	0.95
TRPML1-TFEB pathway	inhibits	pathway	0.93
Type I photodynamic therapy	associated_with	process	0.92
DTG	upregulates	drug	0.90
FOXO1	regulates	gene	0.90
31745295	elevate	paper	0.90
Crocetin	suppresses	compound	0.90
HSPA1A	suppresses	gene	0.90
Rg1	associated_with	compound	0.90
curcumin	inhibits	drug	0.90
selenium-containing compound	associated_with	compound	0.90
Icariin	inhibits	compound	0.90
Mitochondrial Dysfunction	causes	process	0.90
PPARGC1A	regulates	gene	0.90
stroke	causes	disease	0.90
GJA1-20k	suppresses	protein	0.90
Dolutegravir	upregulates	drug	0.88
Paeoniflorin	modulates	compound	0.85
AKT	modulates	protein	0.85
PPARGC1A	modulates	gene	0.85
Quercetier	downregulates	compound	0.85
2,2,6,6-tetramethylpiperidine-1-oxyl	associated_with	compound	0.85
CREBBP	regulates	gene	0.85
SLC15A3	regulates	protein	0.85
Photodynamic Therapy	mediates	process	0.85
PRKAA1	regulates	gene	0.80
AMYLOID-BETA	associated_with	protein	0.80
MICROGLIA	releases	cell_type	0.80
Tryptamine	associated_with	compound	0.80
SIRT3	regulates	gene	0.80
Egcg	modulates	compound	0.80
5-fluorouracil	suppresses	drug	0.80
ischemia-reperfusion injury	increases	disease	0.80
APOE	increases	gene	0.80
ERK	inhibits	protein	0.75
amyloid beta	activates	protein	0.70
hyperphosphorylated tau	activates	protein	0.70
Ginsenoside Rb1	inhibits	drug	0.70
mitochondrial dysfunction	activates	process	0.70
melatonin	inhibits	drug	0.70
Ischemic stroke	associated_with	disease	0.70
Ischemia/reperfusion injury	activates	process	0.70
Amyloid β	activates	protein	0.70
ethanol	activates	drug	0.70
intraocular pressure	activates	process	0.70
autophagy	regulates	process	0.70
lipid droplet formation	activates	process	0.70
Tau protein	activates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning REACTIVE OXYGEN SPECIES in their description or question text

No additional research found