concept

BBB DISRUPTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BBB DISRUPTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

1Hypotheses

4Analyses

9Outgoing

16Incoming

6Experiments

4Debates

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💡 Concept Info

Name	BBB DISRUPTION
Related Diseases	NEURODEGENERATION, SEPSIS, STROKE

Pathway Diagram

graph TD
    BBB_DISRUPTION[BBB DISRUPTION]
    BBB_DISRUPTION -.biomarker for.-> Neuronal_Damage[Neuronal Damage]
    BBB_DISRUPTION -->|inhibits| MICROGLIA[MICROGLIA]
    BBB_DISRUPTION -->|exacerbates| NEURODEGENERATION[NEURODEGENERATION]
    Cellular_Biomarkers[Cellular Biomarkers] -.biomarker for.-> BBB_DISRUPTION
    Molecular_Biomarkers[Molecular Biomarkers] -.biomarker for.-> BBB_DISRUPTION
    Imaging_Biomarkers[Imaging Biomarkers] -.biomarker for.-> BBB_DISRUPTION
    reactive_oxygen_species[reactive oxygen species] -->|activates| BBB_DISRUPTION
    STROKE[STROKE] -->|activates| BBB_DISRUPTION
    SEPSIS[SEPSIS] -->|activates| BBB_DISRUPTION

Outgoing (9)

Target	Relation	Type	Str
plasma NfL elevation	causes	phenotype	0.90
neurofilament-derived peptide permeability	causes	mechanism	0.90
Neuronal Damage	biomarker_for	phenotype	0.85
neuroinflammation	contributes_to	mechanism	0.80
NEURODEGENERATION	exacerbates	phenotype	0.70
MICROGLIA	inhibits	cell_type	0.70
neuroinflammation	causes	process	0.70
HYPOTHALAMUS	associated_with	brain_region	0.50
AMYLOID PET	associated_with	biomarker	0.50

Incoming (16)

Source	Relation	Type	Str
Bbb Permeability	associated_with	biomarker	0.90
35361905	is a hallmark of	paper	0.90
36982361	has been shown to play a role in	paper	0.90
Neurodegeneration	associated_with	phenotype	0.85
Cellular Biomarkers	biomarker_for	biomarker	0.85
Molecular Biomarkers	biomarker_for	biomarker	0.85
Imaging Biomarkers	biomarker_for	biomarker	0.85
edema	associated_with	phenotype	0.70
PDGFRβ inhibition	causes	process	0.70
STROKE	activates	disease	0.70
ferroptosis	causes	mechanism	0.70
global ischemia-reperfusion	causes	process	0.70
reactive oxygen species	activates	process	0.70
SEPSIS	activates	disease	0.65
33208141	correlates with	paper	0.60
AQP4	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Piezoelectric Nanochannel BBB Disruption	0.519	neurodegeneration	Blood-brain barrier transport mechanisms

Mentioning Analyses (4)

Scientific analyses that reference this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.940

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760

How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer'

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.580

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.618

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$130,000
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Dolutegravir induces endoplasmic reticulum stress at the blood-brain barrier. [PMID:39985305]	Huang C, Qu QR, Hoque MT, Bendayan R	FASEB J	2025	1
Profiling Tight Junction Protein Expression in Brain Vascular Malformations. [PMID:40429705]	Pedrosa L, Mosteiro A, Reyes L, Amaro S,	Int J Mol Sci	2025	1
Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation o [PMID:33280500]	Yang Z, Lin P, Chen B, Zhang X, Xiao W,	Autophagy	2021	1
ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818]	["Li X", "Huang J", "Zhou Y", "Chen X",	International journal of pharm	2026	0
Claudins proteins in brain tumors: expression patterns and therapeutic target. [PMID:41399659]	["Romanowicz A", "\u0141ukaszewicz-Zaj\u	Biochemia medica	2026	0
Testicular Gap (CX43) and Tight Junction (OCLN, CLDN3, 5 and 11) Components in t [PMID:41594443]	Goericke-Pesch S, Röhrs L, Wallrabenstei	Animals : an open access journ	2026	0
Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-r [PMID:40994007]	["Cueva Vargas J", "Belforte N", "Vidal-	Molecular therapy : the journa	2026	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Artemether Improves Aβ [PMID:40493345]	["Cai J", "Liu Y", "Gong L", "Deng S", "	Molecular neurobiology	2025	0
Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-r [PMID:39975311]	["Cueva-Vargas J", "Belforte N", "Vidal-	bioRxiv : the preprint server	2025	0
Mesenchymal Stem Cells Restore Endothelial Integrity and Alleviate Emotional Imp [PMID:40244194]	["Chen A", "Duan Y", "Zhou S", "Du F", "	International journal of molec	2025	0
Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional p [PMID:40018968]	Gowrikumar S, Tarudji A, McDonald BZ, Ba	Tissue barriers	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-b [PMID:36969875]	["Huang C", "Hoque T", "Bendayan R"]	Frontiers in pharmacology	2023	0
Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated [PMID:28490769]	Du Y, Xu JT, Jin HN, Zhao R, Zhao D, Du	Scientific reports	2017	0
Anti-inflammatory activity of Barleria lupulina: Identification of active compou [PMID:27660013]	["Senger D", "Hoang M", "Kim K", "Li C",	Journal of ethnopharmacology	2016	0

Debates (4)

Multi-agent debates referencing this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

closed · Rounds: 4 · Score: 0.73 · 2026-04-25

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

The abstract identifies APOE4 association with increased TDP-43 pathology but th

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

Related Research

Hypotheses and analyses mentioning BBB DISRUPTION in their description or question text

No additional research found