| Gene Symbol | PLIN4 |
| Function | encodes a member of the perilipin family of proteins that are essential regulators of lipid droplet formation, storage, and mobilization. |
| Primary Expression | neurons and glial cells, where they participate in lipid droplet dynamics relevant to neurodegenerative processes in Alzheimer's disease (AD), Parkins |
| Molecular Weight | 50 kDa |
| Amino Acids | 456 aa |
| Ensembl ID | ENSG00000146383 |
| GeneCards | PLIN4 |
| Human Protein Atlas | PLIN4 |
| PLIN1-3 | Emerged in vertebrates with the appearance of adipose tissue |
| PLIN4 | Conserved in mammals with highest expression in adipocytes |
| PLIN5 | Evolutionarily ancient, present in all vertebrates |
| Direct binding | Hydrophobic interactions with the lipid droplet surface |
| Protein-protein interactions | Associates with other perilipin family members |
| Phosphorylation regulation | Post-translational modifications modulate droplet association |
| Adipose tissue | Highest expression in white and brown adipose tissue |
| Associated Diseases | neurodegeneration |
| Interactions | BCL2, CARD14, MITOPHAGY, TBC1D24 |
| KG Connections | 85 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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