gene

IDUA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IDUA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

2Hypotheses

0Analyses

17Outgoing

14Incoming

0Experiments

0Debates

Summary

IDUA is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, implicated in, activates. Associated with Aging, Alzheimer, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IDUA
Full Name	Alpha-L-iduronidase
Chromosome	4p16.3
Protein Type	Hydrolase
Function	Heparan sulfate degradation: IDUA removes iduronic acid residues
Molecular Weight	76 kDa
Amino Acids	653 aa
UniProt ID	P35475
NCBI Gene ID	3419
Ensembl ID	ENSG00000127418
OMIM	609014
GeneCards	IDUA
Human Protein Atlas	IDUA
Acid-base catalysis	Residues in the active site facilitate hydrolysis
Substrate specificity	Recognizes the non-reducing end of heparan sulfate and dermatan sulfate
Associated Diseases	neurodegeneration
Interactions	TAU
KG Connections	31 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IDUA — AlphaFold P35475 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IDUA Gene

gene · 1855 words

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Pathway Diagram

graph TD
    IDUA["IDUA"]
    Alzheimer{"Alzheimer"}
    IDUA -->|"therapeutic target"| Alzheimer
    Aging{"Aging"}
    IDUA -->|"therapeutic target"| Aging
    Ms{"Ms"}
    IDUA -->|"therapeutic target"| Ms
    TAU["TAU"]
    IDUA -->|"activates"| TAU
    GRN["GRN"]
    IDUA -->|"therapeutic target"| GRN
    neurodegeneration["neurodegeneration"]
    IDUA -->|"implicated in"| neurodegeneration
    ACE["ACE"]
    ACE -->|"therapeutic target"| IDUA
    TREM2["TREM2"]
    TREM2 -->|"therapeutic target"| IDUA
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| IDUA
    PILRA["PILRA"]
    PILRA -->|"therapeutic target"| IDUA
    style IDUA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:IDUA	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
SMPD1	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
TAU	activates	gene	0.60
GRN	therapeutic_target	gene	0.60
INFLAMMATION	regulates	gene	0.60
RNA	regulates	gene	0.60
CTSD	associated_with	gene	0.60
INPP5D	co_discussed	gene	0.50
RNA	co_discussed	gene	0.50
NLRP1	co_discussed	protein	0.50
SMPD1	co_discussed	gene	0.50

Incoming (14)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:IDUA	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
GENES	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
SMPD1	associated_with	gene	0.60
TREM2	therapeutic_target	gene	0.60
PILRA	therapeutic_target	gene	0.60
ACE	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
GENES	co_discussed	gene	0.50
CTSD	co_discussed	gene	0.50
MICROGLIA	co_discussed	cell_type	0.40
IBA1	co_discussed	protein	0.40

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Residual Vascular Amyloid Prevents Complete CSF p-tau217 Nor	0.585	-	Can CSF p-tau217 normalization serve as
Individual Baseline Variability in p-tau217 Half-Life Dictat	0.335	-	Can CSF p-tau217 normalization serve as

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IDUA in their description or question text

No additional research found