protein 973 words KG: PIK3CAPROTEIN
Contents

PI3K p110α Protein

🔬 Protein Info
Gene SymbolPIK3CA
AliasesPIK3CAPROTEIN
Chromosome3q26.32
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight120 kDa
Amino Acids068 aa
Exons21
PathwaysPI3K, mTOR
GeneCardsPIK3CA
Human Protein AtlasPIK3CA
Associated DiseasesAging, Als, Breast cancer
Known Drugs/CompoundsAlpelisib, Apitolisib, Chrysotoxine, Paxalisib, rapamycin
InteractionsACVR1, AKT, AKT1, AKT3, AND, APOPTOSIS
KG Connections735 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

APOE-Dependent Autophagy Restoration
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (9)

VSMC cholesterol efflux and P2RY12 signaling
exploratory · proposed · Score: 0.90
Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90
S-equol-induced ferroptosis mechanism in TNBC cells
exploratory · proposed · Score: 0.90
In vivo autophagy modulation in atherosclerotic mice
validation · proposed · Score: 0.85
P2RY12-MTOR pathway interaction in VSMCs
exploratory · proposed · Score: 0.85

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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