gene 2,037 words KG: NRP1
Contents

NRP1 Gene

🧬 Gene Info
Gene SymbolNRP1
Full NameNeuropilin 1
Chromosome10p11.22
Protein TypeReceptor
Functionis a multi-domain transmembrane protein
Molecular Weight140 kDa
Exons27
PathwaysAngiogenesis, Cholesterol, NF-kB signaling, Nf-Kb, Tgf-Β
UniProt IDO14786
NCBI Gene ID4800
Ensembl IDENSG00000099250
OMIM602069
GeneCardsNRP1
Human Protein AtlasNRP1
Associated DiseasesAls, Carcinoma, Diabetes, Hepatocellular Carcinoma, Type 2 Diabetes
InteractionsActin, Akt, AKT, AND, ANG, APOE
KG Connections77 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76

Related Analyses (3)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

NGF (Redirect)
redirect · KG edge: activates
ANG — Angiogenin
gene · KG edge: activates
CD14 — CD14 Molecule
gene · KG edge: associated_with
CD8 Gene
gene · KG edge: causes
CXCL10 - C-X-C Motif Chemokine Ligand 10
gene · KG edge: causes

Knowledge Graph (12 edges)

TRKA interacts_with NRP1
NRP1 activates NGF
NRP1 inhibits GAIN
ANG activates NRP1
NRP1 activates APOE
NRP1 activates SLC44A2
DES activates NRP1
VEGF therapeutic_target NRP1
TREM2 causes NRP1
CD14 causes NRP1

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