protein

NMNAT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMNAT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

15Outgoing

7Incoming

0Experiments

0Debates

Summary

Page for NMNAT2 Protein

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🔬 Protein Info

Gene Symbol	NMNAT2
Full Name	NMN Adenylyltransferase 2
Chromosome	1p36.22
Protein Type	Enzyme
Function	NMNAT2 is a cytosolic enzyme that catalyzes the conversion of NMN (nicotinamide mononucleotide) to NAD+ (nicotinamide adenine dinucleotide).
Subcellular Localization	**: Cytosolic, enriched in axons
Molecular Weight	46.2 kDa
Pathways	Complement, Immune Response, Mapk
UniProt ID	Q9H0M0
NCBI Gene ID	23257
Ensembl ID	ENSG00000145425
OMIM	608401
GeneCards	NMNAT2
Human Protein Atlas	NMNAT2
Associated Diseases	neurodegeneration
Interactions	AND, AXON, C4B, COMPLEMENT, MAPK, NEURODEGENERATIVE DISEASES
KG Connections	22 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NMNAT2 — AlphaFold Q9H0M0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NMNAT2 Gene

gene · 584 words

→

NMNAT2 Protein

protein · 680 words

→

Pathway Diagram

graph TD
    NMNAT2("NMNAT2")
    Ms{"Ms"}
    NMNAT2 -->|"activates"| Ms
    Als{"Als"}
    NMNAT2 -->|"activates"| Als
    Inflammation{"Inflammation"}
    NMNAT2 -->|"activates"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    NMNAT2 -->|"activates"| Neuroinflammation
    Neuropathy{"Neuropathy"}
    NMNAT2 -->|"activates"| Neuropathy
    Mapk(["Mapk"])
    NMNAT2 -->|"activates"| Mapk
    C4B["C4B"]
    NMNAT2 -->|"activates"| C4B
    COMPLEMENT["COMPLEMENT"]
    NMNAT2 -->|"activates"| COMPLEMENT
    Immune_Response(["Immune Response"])
    NMNAT2 -->|"activates"| Immune_Response
    Complement(["Complement"])
    NMNAT2 -->|"activates"| Complement
    MAPK["MAPK"]
    MAPK -->|"activates"| NMNAT2
    SARM1["SARM1"]
    SARM1 -->|"activates"| NMNAT2
    AXON["AXON"]
    AXON -->|"protects_against"| NMNAT2
    AND["AND"]
    AND -->|"activates"| NMNAT2
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| NMNAT2

Outgoing (15)

Target	Relation	Type	Str
Neuroinflammation	activates	disease	0.65
Neuropathy	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
SARM1	activates	gene	0.60
macrophages	expressed_in	cell_type	0.60
astrocytes	expressed_in	cell_type	0.60
oligodendrocytes	expressed_in	cell_type	0.60
NRP1	activates	gene	0.60
Mapk	activates	pathway	0.60
COMPLEMENT	activates	gene	0.60
Immune Response	activates	pathway	0.60
Complement	activates	pathway	0.60
C4B	activates	gene	0.60

Incoming (7)

Source	Relation	Type	Str
MAPK	activates	gene	0.60
SARM1	activates	gene	0.60
AXON	protects_against	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
AXON	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NMNAT2 in their description or question text

No additional research found