protein 526 words KG: NRP1PROTEIN
Contents

Neuropilin-1 (NRP1) Protein

🔬 Protein Info
Gene SymbolNRP1
Full NameNeuropilin 1
Chromosome10p11.22
Protein TypeReceptor
Functionis a multi-domain transmembrane protein
Subcellular Localization</span><span class="infobox-value">Plasma membrane, endosomes</span></div>
Molecular Weight140 kDa
Exons27
PathwaysAngiogenesis, Cholesterol, NF-kB signaling, Nf-Kb, Tgf-Β
UniProt IDO14786
NCBI Gene ID4800
Ensembl IDENSG00000099250
OMIM602069
GeneCardsNRP1
Human Protein AtlasNRP1
Associated DiseasesAls, Carcinoma, Diabetes, Hepatocellular Carcinoma, Type 2 Diabetes
InteractionsActin, Akt, AKT, AND, ANG, APOE
KG Connections77 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (21)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
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Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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