gene

NCL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

1Hypotheses

0Analyses

50Outgoing

22Incoming

0Experiments

0Debates

Summary

NCL is a gene implicated in neurodegeneration research. Key relationships include: involved in, activates, regulates. Associated with Als, Alzheimer's Disease, Autoimmune Diseases. Connected to 32 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NCL
Full Name	Nucleolin
Chromosome	2q37.1
Function	Nucleolin performs diverse cellular functions
Primary Expression	Nucleolus, Brain (neurons, hippocampus, cortex)
Pathways	Microrna
UniProt ID	P19367
NCBI Gene ID	4690
Ensembl ID	ENSG00000115053
OMIM	164035
GeneCards	NCL
Human Protein Atlas	NCL
Associated Diseases	ALS, Alzheimer's Disease, autoimmune diseases, neurodegeneration, viral infections
Interactions	AIF1, ATP, BECN1, CTSB, CTSD, CTSL
KG Connections	72 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NCL — AlphaFold P19367 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NCL["NCL (Nucleolin)"]
    
    %% Core cellular processes
    NCL -->|"regulates"| RNA_Transcription["RNA Transcription"]
    NCL -->|"processes"| rRNA_Processing["rRNA Processing"]
    NCL -->|"stabilizes"| mRNA_Stabilization["mRNA Stabilization"]
    NCL -->|"facilitates"| DNA_Replication["DNA Replication"]
    NCL -->|"remodels"| Chromatin_Remodeling["Chromatin Remodeling"]
    
    %% Gene regulation
    NCL -->|"regulates"| HIPPO["HIPPO Pathway"]
    NCL -->|"controls"| MicroRNA["MicroRNA Processing"]
    NCL -->|"activates"| ERK["ERK Signaling"]
    
    %% Cell fate processes
    RNA_Transcription -->|"promotes"| Cell_Proliferation["Cell Proliferation"]
    NCL -->|"upregulates"| Cell_Proliferation
    NCL -->|"modulates"| Apoptosis["Apoptosis"]
    Cell_Proliferation -->|"leads to"| Cytokinesis["Cytokinesis"]
    
    %% Neurodegeneration context
    NCL -->|"associated with"| Alzheimers["Alzheimer's Disease"]
    NCL -->|"therapeutic target"| ALS["ALS"]
    
    %% Pathological outcomes
    ERK -->|"promotes"| Invasion["Cell Invasion"]
    NCL -->|"activates"| Cancer["Cancer/Carcinoma"]
    Cell_Proliferation -->|"contributes to"| Cancer
    
    %% Styling
    style NCL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style rRNA_Processing fill:#1b5e20,stroke:#2e7d32
    style mRNA_Stabilization fill:#1b5e20,stroke:#2e7d32
    style HIPPO fill:#4a1a6b,stroke:#7b1fa2
    style ERK fill:#4a1a6b,stroke:#7b1fa2
    style Alzheimers fill:#7d4200,stroke:#ef6c00
    style ALS fill:#7d4200,stroke:#ef6c00
    style Cancer fill:#ef5350,stroke:#c62828
    style Apoptosis fill:#1b5e20,stroke:#2e7d32

Outgoing (50)

Target	Relation	Type	Str
MADD	regulates	protein	0.95
Histone Chaperone Activity	mediates	mechanism	0.95
iCCA cell proliferation	promotes	process	0.93
RNA Transcription	regulates	process	0.90
Chromatin Remodeling	involved_in	process	0.90
Gene Expression	regulates	process	0.90
Histone Chaperone Activity	involved_in	process	0.90
Cancer	biomarker_for	disease	0.90
DNA recombination	regulates	process	0.85
cancer cell proliferation	drives	phenotype	0.85
Cancer	upregulates	disease	0.85
mRNA Stabilization	involved_in	process	0.80
apoptosis	regulates	process	0.80
DNA Recombination	involved_in	process	0.80
DNA Replication	involved_in	process	0.80
rRNA Processing	involved_in	process	0.80
Cell Proliferation	upregulates	process	0.80
Cytokinesis	involved_in	process	0.80
neurons	expressed_in	cell_type	0.80
drug resistance	contributes_to	phenotype	0.75
Alzheimer's Disease	associated_with	disease	0.75
Drug Resistance	involved_in	phenotype	0.70
Apoptosis	involved_in	process	0.70
autophagy pathway	participates_in	pathway	0.70
Autoimmune Diseases	associated_with	disease	0.70
Viral Infections	associated_with	disease	0.70
viral infections	implicated_in	disease	0.70
autoimmune diseases	implicated_in	disease	0.70
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	therapeutic_target	disease	0.65
HIPPO	regulates	gene	0.60
Differentiation	therapeutic_target	pathway	0.60
Microrna	regulates	pathway	0.60
Hippo Pathway	therapeutic_target	pathway	0.60
GENES	regulates	gene	0.60
blood-brain barrier	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
neurodegeneration	causes	disease	0.60
SQSTM1	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
TPP1	interacts_with	gene	0.60
ERK	activates	gene	0.60
Invasion	activates	pathway	0.60
Rna Splicing	activates	pathway	0.60
Mapk	activates	pathway	0.60
Erk Signaling	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
TRIM2	inhibits	gene	0.60
TRIM2	co_expressed_with	gene	0.50

Incoming (22)

Source	Relation	Type	Str
P300	phosphorylates	protein	0.90
MST1	regulates	gene	0.60
QKI	regulates	gene	0.60
BECN1	activates	gene	0.60
CTSD	associated_with	gene	0.60
AIF1	interacts_with	gene	0.60
CTSB	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
CTSL	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
IBA1	interacts_with	gene	0.60
LAMP1	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
LDL	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
ALS	implicated_in	gene	0.60
LC3B	activates	gene	0.60
CTSD	causes	gene	0.60
ATP13A2	implicated_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
STMN2 Cryptic Exon Inclusion is the Earliest Loss-of-Functio	0.702	ALS	Causal Sequence of TDP-43 Nuclear Cleara

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NCL in their description or question text

No additional research found

NCL