gene

QKI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about QKI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

13Outgoing

4Incoming

0Experiments

0Debates

Summary

Page for QKI Gene

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🧬 Gene Info

Gene Symbol	QKI
Chromosome	6q26
Function	Through this mechanism, QKI regulates
Subcellular Localization	["@nature2007"]
Molecular Weight	38 kDa
Pathways	Microrna
Ensembl ID	ENSG00000112531
GeneCards	QKI
Human Protein Atlas	QKI
Alternative splicing	QKI modulates the splicing of pre-mRNAs to generate neuronal and glial-specific isoforms
mRNA stability	QKI binding to target mRNAs can either stabilize or destabilize transcripts
Translation	QKI can repress or activate translation of target mRNAs
mRNA localization	QKI facilitates transport of mRNAs to specific subcellular compartments
Associated Diseases	ALS
Interactions	NRF2, SMAD7
KG Connections	17 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

QKI Gene

gene · 743 words

→

QKI Protein

protein · 906 words

→

Pathway Diagram

flowchart TD
    N0["QKI"]
    N1["Als"]
    N0 -->|"therapeutic target"| N1
    N2["NCL"]
    N0 -->|"regulates"| N2
    N3["HIPPO"]
    N0 -->|"regulates"| N3
    N4["GENES"]
    N0 -->|"regulates"| N4
    N5["Hippo Pathway"]
    N0 -->|"therapeutic target"| N5
    N6["Differentiation"]
    N0 -->|"therapeutic target"| N6
    N7["Microrna"]
    N0 -->|"regulates"| N7
    N8["MST1"]
    N8 -->|"regulates"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 pathway
    class N6 pathway
    class N7 pathway
    class N8 gene

Outgoing (13)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.65
SMAD7	regulates	gene	0.60
HIPPO	regulates	gene	0.60
GENES	regulates	gene	0.60
Hippo Pathway	therapeutic_target	pathway	0.60
Differentiation	therapeutic_target	pathway	0.60
SMAD7	activates	gene	0.60
Microrna	regulates	pathway	0.60
ALS	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
senescence	participates_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
NCL	regulates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
MST1	regulates	gene	0.60
NRF2	activates	gene	0.60
NRF2	regulates	gene	0.60
G3BP1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning QKI in their description or question text

No additional research found