concept

CHROMATIN REMODELING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHROMATIN REMODELING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

2Hypotheses

0Analyses

17Outgoing

31Incoming

3Experiments

0Debates

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💡 Concept Info

Name	CHROMATIN REMODELING
Key Genes/Proteins	AMYLOID, BDNF, BRD4, CREB, HDAC3, P300
Related Diseases	INFLAMMATION, OXIDATIVE STRESS, SENESCENCE
Related Pathways	DNA DAMAGE RESPONSE

Pathway Diagram

graph TD
    CHROMATIN_REMODELING["CHROMATIN REMODELING"]
    CHROMATIN_REMODELING -->|"mediates"| Smooth_Muscle_Cell_Phenotypic_["Smooth Muscle Cell Phenotypic Alterations"]
    CHROMATIN_REMODELING -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
    CHROMATIN_REMODELING -->|"activates"| alcohol_use_disorder["alcohol use disorder"]
    CHROMATIN_REMODELING -->|"activates"| EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"]
    NCL["NCL"] -->|"involved_in"| CHROMATIN_REMODELING
    Histone_Acetylation["Histone Acetylation"] -->|"involved_in"| CHROMATIN_REMODELING
    STAT3["STAT3"] -->|"modulates"| CHROMATIN_REMODELING
    NUCLEOLIN["NUCLEOLIN"] -->|"involved_in"| CHROMATIN_REMODELING
    PBRM1["PBRM1"] -->|"involved_in"| CHROMATIN_REMODELING
    HDAC_Inhibitors["HDAC Inhibitors"] -->|"modulates"| CHROMATIN_REMODELING
    CLASS_I_HDACS["CLASS I HDACS"] -->|"regulates"| CHROMATIN_REMODELING
    alcohol["alcohol"] -->|"regulates"| CHROMATIN_REMODELING

Outgoing (17)

Target	Relation	Type	Str
Smooth Muscle Cell Phenotypic Alterations	mediates	phenotype	0.95
Alzheimer's Disease	associated_with	disease	0.85
synaptic plasticity	regulates	process	0.70
alcohol use disorder	activates	disease	0.70
INTERNEURONS	regulates	cell_type	0.65
SENESCENCE	causes	phenotype	0.60
BDNF	inhibits	gene	0.60
SENESCENCE	activates	phenotype	0.60
BDNF	causes	gene	0.60
ASTROCYTE	activates	cell_type	0.60
ASTROCYTE	regulates	cell_type	0.60
INFLAMMATION	implicated_in	phenotype	0.55
INTERNEURONS	expressed_in	cell_type	0.55
SPERMIDINE	associated_with	drug	0.50
RAPAMYCIN	associated_with	drug	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
DNA DAMAGE RESPONSE	associated_with	pathway	0.45

Incoming (31)

Source	Relation	Type	Str
NUCLEOLIN	involved_in	protein	0.90
NCL	involved_in	protein	0.90
Histone Acetylation	involved_in	process	0.90
STAT3	modulates	protein	0.90
HDAC Inhibitors	modulates	drug	0.85
PBRM1	involved_in	protein	0.85
HUNTINGTIN	regulates	protein	0.80
HSV-gB	mediates	protein	0.80
CLASS I HDACS	regulates	enzyme	0.80
alcohol	regulates	drug	0.70
SIRT1	modifies	gene	0.65
AMYLOID	regulates	protein	0.65
AMYLOID	causes	protein	0.65
STING	activates	gene	0.60
TBK1	activates	gene	0.60
P300	causes	gene	0.60
EZH2	activates	gene	0.60
IRF3	activates	gene	0.60
BRD4	inhibits	gene	0.60
HDAC3	regulates	gene	0.60
OXIDATIVE STRESS	regulates	phenotype	0.60
TNF	targets	gene	0.60
TET2	interacts_with	gene	0.60
CREB	causes	gene	0.60
Alzheimer	biomarker_for	disease	0.55
Autoimmune	biomarker_for	disease	0.55
Cancer	biomarker_for	disease	0.55
Als	activates	disease	0.55
Inflammation	activates	disease	0.55
Als	biomarker_for	disease	0.55
APOPTOSIS	implicated_in	process	0.35

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Chromatin Remodeling-Mediated Nutrient Sensing Restoration	0.914	neurodegeneration	Epigenetic reprogramming in aging neuron
Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat	0.690	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Acteoside treatment in LPS-induced SALI mouse model	validation	sepsis-associated acute lung i	0.900	LPS-induced SALI mouse model	proposed	N/A
Nrf2 inhibitor ML385 mechanism validation experiment	exploratory	sepsis-associated acute lung i	0.850	RAW264.7 cells and/or mouse mo	proposed	N/A
Acteoside effects on RAW264.7 macrophage cells	exploratory	sepsis-associated acute lung i	0.850	RAW264.7 cells	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHROMATIN REMODELING in their description or question text

No additional research found