gene

TRIM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

5Hypotheses

3Analyses

33Outgoing

8Incoming

1Experiments

3Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	TRIM2
Chromosome	4q31.3
Protein Type	Ligase
Function	encodes a neuron-specific E3 ubiquitin ligase that plays critical roles in protein quality control, axonal maintenance, cytoskeletal dynamics, and cellular defense mechanisms.
Molecular Weight	85 kDa
Amino Acids	741 aa
UniProt ID	Q9C0B1
NCBI Gene ID	23321
Ensembl ID	ENSG00000109654
OMIM	614434
GeneCards	TRIM2
Human Protein Atlas	TRIM2
Associated Diseases	ALS
Interactions	NCL
KG Connections	41 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRIM2 — AlphaFold Q9C0B1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["TRIM2"]
    N1["TRIM28"]
    N0 -->|"co discussed"| N1
    N2["WAS"]
    N0 -->|"co discussed"| N2
    N3["CANCER"]
    N3 -->|"co discussed"| N0
    N4["HDAC5"]
    N4 -->|"co discussed"| N0
    N5["SLC7A1"]
    N5 -->|"co discussed"| N0
    N6["SLC7A11"]
    N6 -->|"co discussed"| N0
    N7["STAT6"]
    N7 -->|"co discussed"| N0
    N8["STING"]
    N8 -->|"co discussed"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 protein
    class N2 protein
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene

Outgoing (33)

Target	Relation	Type	Str
ALS	associated_with	disease	0.60
TRIM28	co_discussed	protein	0.50
WAS	co_discussed	protein	0.50
ACTB	co_discussed	gene	0.40
BECN1	co_discussed	gene	0.40
C9ORF72	co_discussed	gene	0.40
SMCR8	co_discussed	gene	0.40
CALCOCO2	co_discussed	gene	0.40
NDP52	co_discussed	gene	0.40
FUS	co_discussed	protein	0.40
LC3	co_discussed	protein	0.40
NBR1	co_discussed	gene	0.40
GNAL	co_discussed	gene	0.40
OPTN	co_discussed	gene	0.40
OPTINEURIN	co_discussed	protein	0.40
SQSTM1	co_discussed	gene	0.40
P62	co_discussed	protein	0.40
TAX1BP1	co_discussed	gene	0.40
TOLLIP	co_discussed	gene	0.40
ULK1	co_discussed	gene	0.40
UBIQUITIN	co_discussed	protein	0.40
AUTOPHAGY	co_discussed	process	0.40
OXIDATIVE STRESS	co_discussed	process	0.40
NEURODEGENERATIVE DISEASES	co_discussed	disease	0.40
ACTIN	co_discussed	protein	0.40
ALS	co_discussed	disease	0.40
AMYOTROPHIC LATERAL SCLEROSIS	co_discussed	gene	0.40
FTD	co_discussed	disease	0.40
DEMENTIA	co_discussed	gene	0.40
RNA	co_discussed	gene	0.40
MAP1LC3	co_discussed	gene	0.40
NES	co_discussed	protein	0.40
G3BP1	co_discussed	gene	0.40

Incoming (8)

Source	Relation	Type	Str
NCL	inhibits	gene	0.60
NCL	co_expressed_with	gene	0.50
CANCER	co_discussed	gene	0.50
HDAC5	co_discussed	gene	0.50
SLC7A1	co_discussed	gene	0.50
SLC7A11	co_discussed	gene	0.50
STAT6	co_discussed	gene	0.50
STING	co_discussed	gene	0.50

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TRIM21 as a 'Phase Separation Thermostat' via Catalytic Reve	0.700	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat
ALS-Associated G3BP1/2 Mutations Disrupt TRIM21 Binding Inte	0.585	neurodegeneration	How do pathological stress granules in n
TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gr	0.548	neurodegeneration	What determines the spatial organization
Hyperphosphorylated TDP-43 Traps TRIM21 Into Inactive Comple	0.487	neurodegeneration	How do pathological stress granules in n
Casein Kinase 2 (CK2)-Mediated Hyperphosphorylation of G3BP1	0.440	neurodegeneration	How do pathological stress granules in n

Mentioning Analyses (3)

Scientific analyses that reference this entity

What determines the spatial organization of autophagy receptors at stress granul

neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.633

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.730

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.717

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TRIM21 E3 ubiquitin ligase screen for stress granule regulation	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

The study shows TRIM21 and autophagy receptors can eliminate both physiological

closed · Rounds: 4 · Score: 0.75 · 2026-04-22

The study shows that G3BP1 ubiquitination inhibits LLPS in vitro, but the molecu

closed · Rounds: 4 · Score: 0.79 · 2026-04-21

SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout

closed · Rounds: 4 · Score: 0.69 · 2026-04-21

Related Research

Hypotheses and analyses mentioning TRIM2 in their description or question text

No additional research found