concept

LINC00599

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LINC00599: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

0Analyses

25Outgoing

9Incoming

5Experiments

0Debates

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💡 Concept Info

Name	LINC00599
Key Genes/Proteins	AND, G3BP1, MYH9, Myosin
Related Diseases	Cardiovascular, Hypertension, Hypoxia, Hypoxic Conditions, Hypoxic Pulmonary Hypertension

Pathway Diagram

graph TD
    LINC00599["LINC00599"]
    LINC00599 -->|"promotes"| Pulmonary_Hypertension["Pulmonary Hypertension"]
    LINC00599 -->|"interacts"| G3BP1["G3BP1"]
    LINC00599 -->|"interacts"| MYH9["MYH9"]
    LINC00599 -->|"expressed in"| Pulmonary_Arterial_Smooth_Musc["Pulmonary Arterial Smooth Muscle Cells"]
    LINC00599 -->|"expressed in"| Pulmonary_Artery_Smooth_Muscle["Pulmonary Artery Smooth Muscle Cells"]
    LINC00599 -->|"involved_in"| Vascular_Remodeling["Vascular Remodeling"]
    Hypoxia["Hypoxia"] -->|"upregulates"| LINC00599
    G3BP1 -->|"interacts"| LINC00599
    MYH9 -->|"interacts"| LINC00599
    ZNF263["ZNF263"] -->|"regulates"| LINC00599
    RNA["RNA"] -->|"regulates"| LINC00599
    AND["AND"] -->|"activates"| LINC00599

Outgoing (25)

Target	Relation	Type	Str
Pulmonary Hypertension	associated_with	disease	0.95
Hypoxic Conditions	upregulates	phenotype	0.92
MYH9	interacts_with	protein	0.90
Pulmonary Arterial Smooth Muscle Cells	expressed_in	cell_type	0.90
Hypoxic Pulmonary Hypertension	treats	disease	0.90
G3BP1	interacts_with	protein	0.90
Pulmonary Arterial Smooth Muscle Cell Proliferation	promotes	process	0.90
Pulmonary Artery Smooth Muscle Cells	expressed_in	cell_type	0.90
Pulmonary Artery Medial Layer	expressed_in	cell_type	0.90
Stress Granule Formation	modulates	process	0.85
Pulmonary Arterial Smooth Muscle Cell Proliferation	modulates	process	0.85
Vascular Remodeling	modulates	process	0.85
Hypoxia	upregulates	phenotype	0.85
Vascular Remodeling	involved_in	process	0.85
Cardiovascular	activates	disease	0.65
Hypertension	activates	disease	0.65
Ms	activates	disease	0.65
G3BP1	activates	gene	0.60
Rb	activates	protein	0.60
MYH9	activates	gene	0.60
RNA	activates	gene	0.60
RNA	regulates	gene	0.60
AND	activates	gene	0.60
MYH9	regulates	gene	0.60
Myosin	regulates	protein	0.60

Incoming (9)

Source	Relation	Type	Str
Hypoxia	upregulates	phenotype	0.90
G3BP1	interacts_with	protein	0.90
MYH9	interacts_with	gene	0.90
ZNF263	regulates	gene	0.85
MYH9	regulates	gene	0.60
RNA	regulates	gene	0.60
AND	activates	gene	0.60
ZNF263	activates	gene	0.60
G3BP1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
LINC00599 expression analysis in hypoxic PH models	exploratory	Pulmonary hypertension	0.900	Mouse lung tissues and PASMCs	proposed	N/A
LINC00599 role in human PASMC proliferation	exploratory	Pulmonary hypertension	0.900	Human PASMCs	proposed	N/A
LINC00599 knockdown in hypoxic PH mouse model	validation	Pulmonary hypertension	0.850	Murine hypoxic PH models	proposed	N/A
LINC00599-MYH9 liquid-liquid phase separation analysis	exploratory	Pulmonary hypertension	0.850	In vitro phase separation assa	proposed	N/A
ZNF263-mediated LINC00599 transcriptional regulation	exploratory	Pulmonary hypertension	0.800	Cell-based transcriptional ass	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LINC00599 in their description or question text

No additional research found