concept

TREK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

10Outgoing

7Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TREK1
Key Genes/Proteins	FMRPPROTEIN, KCNK2, PRIONPROTEINPRP, PRNP
Related Diseases	CELLULAR_EXCITABILITY, Depression, MEMBRANE_POTENTIAL, Pain, POTASSIUM_LEAK

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TREK1 Neurons

cell · 961 words

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Pathway Diagram

graph TD
    TREK1["TREK1"]
    TREK1 -->|"regulates"| Blood_Brain_Barrier_Function["Blood-Brain Barrier Function"]
    TREK1 -->|"inhibits"| Lymphocyte_Migration["Lymphocyte Migration"]
    TREK1 -->|"expressed in"| Brain_Endothelial_Cells["Brain Endothelial Cells"]
    TREK1 -->|"involved_in"| Depression["Depression"]
    TREK1 -->|"involved_in"| Pain["Pain"]
    TREK1 -->|"involved_in"| Neurodegenerative_Damage["Neurodegenerative Damage"]
    TREK1 -->|"regulates"| MEMBRANE_POTENTIAL["MEMBRANE_POTENTIAL"]
    TREK1 -->|"regulates"| CELLULAR_EXCITABILITY["CELLULAR_EXCITABILITY"]
    KCNK2["KCNK2"] -->|"encodes"| TREK1
    Inflammation["Inflammation"] -->|"downregulates"| TREK1
    PRNP["PRNP"] -->|"binds"| TREK1
    PRIONPROTEINPRP["PRIONPROTEINPRP"] -->|"binds"| TREK1
    FMRPPROTEIN["FMRPPROTEIN"] -->|"binds"| TREK1
    RPS3A["RPS3A"] -->|"interacts"| TREK1
    GABAARECEPTORTHETAPROTEIN["GABAARECEPTORTHETAPROTEIN"] -->|"binds"| TREK1

Outgoing (10)

Target	Relation	Type	Str
Blood-Brain Barrier Function	regulates	process	0.90
Lymphocyte Migration	inhibits	process	0.90
Brain Endothelial Cells	expressed_in	cell_type	0.90
Depression	involved_in	disease	0.75
Pain	involved_in	disease	0.75
Neurodegenerative Damage	involved_in	process	0.75
MEMBRANE_POTENTIAL	regulates	phenotype	0.64
CELLULAR_EXCITABILITY	regulates	phenotype	0.64
POTASSIUM_LEAK	regulates	phenotype	0.64
TEMPERATURE_SENSITIVITY	associated_with	phenotype	0.64

Incoming (7)

Source	Relation	Type	Str
KCNK2	encodes	gene	1.00
Inflammation	downregulates	process	0.85
PRNP	binds	gene	0.80
PRIONPROTEINPRP	binds	protein	0.80
FMRPPROTEIN	binds	protein	0.80
RPS3A	interacts_with	gene	0.70
GABAARECEPTORTHETAPROTEIN	binds	receptor	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TREK1 in their description or question text

No additional research found