Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Heat: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| KCNK2 | activates | gene | 0.95 |
| KCNK10 | activates | gene | 0.95 |
| KCNK4 | activates | gene | 0.95 |
| K2P channel activity | associated_with | process | 0.92 |
| Cellular Excitation | modulates | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Heat Shock Protein 70 Disaggregase Amplification | 0.625 | neurodegeneration | TDP-43 phase separation therapeutics for |
| Tau fibrils expose neuronal phosphatidylserine and heat-shoc | 0.620 | neurodegeneration | Synaptic pruning by microglia in neurode |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Dose-response studies showing therapeutic window without toxici | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Multiscale Computational Modeling of Protein Aggregation Kinetics | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Prion Strain Diversity and Selective Vulnerability in CJD | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Proteasome-Ubiquitin System Dysfunction Validation in Parkinson's Dise | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Protein Aggregation Kinetic Validation Results | validation | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $120,000 |
| Experiment Validation: In vitro ThT Assay | validation | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $160,000 |
| Viral Infections and Alzheimer's Disease — causal mechanisms and thera | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress [PMID:40066224] | Liu H, Zhou Y, Wang Z, Liu D, Li Y, Lai | MedComm (2020) | 2025 | 1 |
| From sleep to cancer to neurodegenerative disease: the crucial role of Hsp70 in [PMID:37643058] | Ghosh S, Vashisth K, Ghosh S, Han SS, Bh | J Biomol Struct Dyn | 2024 | 1 |
| Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteom [PMID:37652020] | Yuan S, Xu F, Li X, Chen J, Zheng J, Man | Cell Rep Med | 2023 | 1 |
| Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancie [PMID:19821156] | Molvarec A, Tamási L, Losonczy G, Madách | Cell Stress Chaperones | 2010 | 1 |
| Integrating NHANES and network toxicology to assess the impact of organophosphat [PMID:41804832] | Dai K, Huang Y, Cai H, Zhong G, Xie Z, W | Toxicology mechanisms and meth | 2026 | 0 |
| Crystal structures reveal phosphorylation-dependent disruption of the heat shock [PMID:41833837] | Stewart M, Paththamperuma C, McCann C, C | Cell stress & chaperones | 2026 | 0 |
| Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbat [PMID:41725010] | Wen M, Li J, Li Y, Hun M, Yang T, Meng Y | Cell & bioscience | 2026 | 0 |
| Single-cell transcriptomics reveal heat shock protein dysregulation in severe SA [PMID:41772029] | Suzuki T, Sato Y, Suzuki M, Fukuda Y, Iw | Scientific reports | 2026 | 0 |
| Heat shock suppresses the innate immune response of bovine endometrial epithelia [PMID:41665179] | Tariq A, Sagheer M, Seekford ZK, Ren J, | Reproduction & fertility | 2026 | 0 |
| Echocardiography Versus Magnetic Resonance Imaging Quantification and Novel Algo [PMID:37890567] | ["Wang T", "Reyaldeen R", "Akyuz K", "Po | The American journal of cardio | 2024 | 0 |
| Integrating network pharmacology and drug side-effect data to explore mechanism [PMID:38308871] | ["Tang M", "Wu Z", "Li F"] | Computers in biology and medic | 2024 | 0 |
| Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 [PMID:39883516] | Liu S, Li L, Liang Y, Tan Y, Wang X, Fen | Briefings in bioinformatics | 2024 | 0 |
| Is targeting angiotensin-converting enzyme 2 (ACE2) a prophylactic strategy agai [PMID:36567123] | ["Li J", "Yan Y", "Dou F", "Gao J"] | Bioscience trends | 2022 | 0 |
| Salmon aquaculture threatens Patagonia. [PMID:33986174] | Juan G Navedo; Luis Vargas-Chacoff | Science (New York, N.Y.) | 2021 | 0 |
| Single-cell RNA sequencing reveals markers of disease progression in primary cut [PMID:34583709] | Rindler K, Jonak C, Alkon N, Thaler FM, | Molecular cancer | 2021 | 0 |
| Using dynamic monitoring of choices to predict and understand risk preferences. [PMID:33234567] | ["Stillman PE", "Krajbich I", "Ferguson | Proceedings of the National Ac | 2021 | 0 |
| A body map of somatic mutagenesis in morphologically normal human tissues. [PMID:34433965] | ["Li R", "Di L", "Li J", "Fan W", "Liu Y | Nature | 2021 | 0 |
| Detrimental effects of air pollution on adult lung function. [PMID:31345990] | Edith B Milanzi; Ulrike Gehring | The European respiratory journ | 2019 | 0 |
| Academy News [PMID:30567890] | Unknown | Neonatal Network | 2018 | 0 |
| Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activate [PMID:28687614] | ["Madhusudhan T", "Wang H", "Ghosh S", " | Blood | 2017 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Heat in their description or question text
No additional research found