gene

GRIA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

21Outgoing

16Incoming

0Experiments

0Debates

Summary

GRIA3 encodes the GluA3 AMPA receptor subunit, critical for fast excitatory synaptic transmission and implicated in Alzheimer's disease, ALS, and X-linked intellectual disability

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🧬 Gene Info

Gene Symbol	GRIA3
Protein Family	AMPA receptor family, ionotropic glutamate receptor family
Function	AMPA receptors containing GluA3 subunits mediate fast excitatory neurotransmission at the vast majority of synapses in the brain.
Subcellular Localization	Postsynaptic membrane, synapse
Molecular Weight	100 kDa
Amino Acids	894 aa
Exons	22
Pathways	Camp Signaling
UniProt ID	[P42263](https://www.uniprot.org/uniprot/P42263)
GeneCards	GRIA3
Human Protein Atlas	GRIA3
Associated Diseases	Neurodegeneration
KG Connections	37 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GRIA3 Gene

gene · 2244 words

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GRIA3 Protein

protein · 659 words

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Pathway Diagram

graph TD
    GRIA3["GRIA3"]
    Schizophrenia{"Schizophrenia"}
    GRIA3 -->|"therapeutic target"| Schizophrenia
    Als{"Als"}
    GRIA3 -->|"therapeutic target"| Als
    Autism{"Autism"}
    GRIA3 -->|"therapeutic target"| Autism
    Depression{"Depression"}
    GRIA3 -->|"therapeutic target"| Depression
    Ms{"Ms"}
    GRIA3 -->|"therapeutic target"| Ms
    KCNK2["KCNK2"]
    GRIA3 -->|"therapeutic target"| KCNK2
    neurodegeneration["neurodegeneration"]
    GRIA3 -->|"implicated in"| neurodegeneration
    KCNMB1["KCNMB1"]
    KCNMB1 -->|"therapeutic target"| GRIA3
    KCNN2["KCNN2"]
    KCNN2 -->|"associated with"| GRIA3
    KCNK2 -->|"therapeutic target"| GRIA3
    style GRIA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (21)

Target	Relation	Type	Str
Neurodegeneration	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Dementia	regulates	disease	0.65
Aging	regulates	disease	0.65
Schizophrenia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Autism	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
EGFR	regulates	gene	0.60
CLU	regulates	gene	0.60
Rb	regulates	protein	0.60
KCNK2	therapeutic_target	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Camp Signaling	regulates	pathway	0.60
Egfr	regulates	protein	0.60
App	associated_with	protein	0.60
AGING	regulates	gene	0.60
PDE4D	regulates	gene	0.60
MAPT	regulates	gene	0.60

Incoming (16)

Source	Relation	Type	Str
EGFR	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
KCNMB1	therapeutic_target	gene	0.60
KCNN2	associated_with	gene	0.60
KCNK2	therapeutic_target	gene	0.60
ACTN2	regulates	gene	0.60
CLU	regulates	gene	0.60
PDE4D	regulates	gene	0.60
AGING	regulates	gene	0.60
DEMENTIA	regulates	gene	0.50
GENES	co_discussed	gene	0.50
MAPT	regulates	gene	0.50
ALZHEIMER	regulates	gene	0.50
actn2	regulates	gene	0.50
Neurodegeneration	associated_with	disease	0.50
FHL1	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRIA3 in their description or question text

No additional research found