| Gene Symbol | IL12B |
| Aliases | Page for IL12B Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Pathways | Er Stress, Blood-Brain Barrier, Autophagy |
| Ensembl ID | ENSG00000167299 |
| GeneCards | IL12B |
| Human Protein Atlas | IL12B |
| IL-12p70 formation | Pairs with IL-12p35 |
| IL-23 formation | Pairs with IL-23p19 |
| p40 homodimer | Acts as IL-12 antagonist |
| Cellular sources | Dendritic cells, macrophages, monocytes, microglia |
| Induction | By LPS, TNF-α, IFN-γ |
| Brain | Elevated in neuroinflammatory conditions |
| Associated Diseases | primary_Sjogren_disease |
| Interactions | AND, ATF4, Chemokine, CLDN5, CXCL1, CXCL2 |
| KG Connections | 87 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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