concept

STAU1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAU1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

164Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	STAU1
Key Genes/Proteins	ALZHEIMER, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOPTOSIS
Related Diseases	Als, ALS, Alzheimer, Alzheimer's disease, Alzheimer'S Disease
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    STAU1["STAU1"]
    style STAU1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    STAU1 -->|"interacts"| MTOR([MTOR])
    STAU1 -.->|"inhibits"| Autophagy["Autophagy"]
    STAU1 -.->|"biomarker for"| Spinocerebellar_Ataxia_Type_2["Spinocerebellar Ataxia Type 2"]
    STAU1 -.->|"biomarker for"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    STAU1 -.->|"biomarker for"| Frontotemporal_Degeneration["Frontotemporal Degeneration"]
    STAU1 -.->|"biomarker for"| Huntington_s_Disease["Huntington's Disease"]
    STAU1 -.->|"biomarker for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    STAU1 -.->|"biomarker for"| Parkinson_s_Disease["Parkinson's Disease"]
    ALS([ALS]) -.->|"protects against"| STAU1
    APOPTOSIS([APOPTOSIS]) -.->|"inhibits"| STAU1
    AND([AND]) -.->|"inhibits"| STAU1
    NEURODEGENERATION([NEURODEGENERATION]) -->|"target for"| STAU1
    C9ORF72([C9ORF72]) -->|"activates"| STAU1

Outgoing (107)

Target	Relation	Type	Str
MTOR	interacts_with	gene	0.95
MTOR	upregulates	gene	0.95
Spinocerebellar Ataxia Type 2	associated_with	disease	0.91
MTOR	activates	gene	0.90
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.90
mTOR Translation	associated_with	process	0.90
Frontotemporal Degeneration	biomarker_for	disease	0.90
Huntington's Disease	biomarker_for	disease	0.90
MTOR	regulates	gene	0.90
Alzheimer's Disease	biomarker_for	disease	0.90
Parkinson's Disease	biomarker_for	disease	0.90
Autophagy	inhibits	process	0.90
Spinocerebellar Ataxia Type 2	biomarker_for	disease	0.90
apoptosis	promotes	process	0.90
P53	activates	gene	0.90
neurodegeneration	associated_with	process	0.90
Parkinson'S Disease	associated_with	disease	0.88
Alzheimer'S Disease	associated_with	disease	0.88
MTOR	binds	protein	0.88
Neurodegeneration	contributes_to	process	0.85
Stress Granule Formation	involved_in	process	0.85
Autophagy-Lysosome Function	inhibits	pathway	0.85
P53	interacts_with	gene	0.85
Neurodegeneration	targets	process	0.85
mTOR	interacts_with	gene	0.80
mTOR	regulates	gene	0.80
KIF5	interacts_with	protein	0.80
RNA Metabolism	mediates	process	0.80
neurodegenerative diseases	associated_with	disease	0.70
mTOR signaling	activates	pathway	0.70
MTOR	promotes	protein	0.70
oxidative stress response	participates_in	pathway	0.70
Frontotemporal Dementia	expressed_in	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Ataxia	expressed_in	disease	0.65
Ataxia	therapeutic_target	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Dementia	expressed_in	disease	0.65
Spinocerebellar Ataxia	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	protects_against	disease	0.65
Ms	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Huntington	associated_with	disease	0.65

Incoming (57)

Source	Relation	Type	Str
C9ORF72	upregulates	gene	0.85
C9ORF72	associated_with	gene	0.80
ATXN2	associated_with	gene	0.80
MTOR	activates	gene	0.60
RNA	regulates	gene	0.60
MTOR	therapeutic_target	gene	0.60
C9ORF72	therapeutic_target	gene	0.60
ALS	associated_with	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
STAU2	associated_with	gene	0.60
ATXN2	inhibits	gene	0.60
HUNTINGTON	associated_with	gene	0.60
MTOR	interacts_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
C9ORF72	expressed_in	gene	0.60
AND	associated_with	gene	0.60
MTOR	expressed_in	gene	0.60
NEURODEGENERATION	causes	gene	0.60
ATXN2	causes	gene	0.60
RNA	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
AND	causes	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AND	inhibits	gene	0.60
ALS	protects_against	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
C9ORF72	activates	gene	0.60
DEMENTIA	expressed_in	gene	0.60
C9ORF72	inhibits	gene	0.60
C9ORF72	causes	gene	0.60
mTOR	interacts_with	entity	0.50
Neurodegeneration	activates	disease	0.50
ATXN2	activates	gene	0.50
disease	activates	disease	0.50
amyotrophic lateral sclerosis	expressed_in	gene	0.50
Neurodegenerative Diseases	expressed_in	disease	0.50
Spinal Cord	expressed_in	cell_type	0.50
disease	expressed_in	disease	0.50
NEURODEGENERATIVE DISEASE	expressed_in	concept	0.50
ALZHEIMER	expressed_in	gene	0.50
PARKINSON	expressed_in	gene	0.50
HUNTINGTON	expressed_in	gene	0.50
Ataxia	expressed_in	disease	0.50
Fibroblast	expressed_in	cell_type	0.50
Spinocerebellar Ataxia	expressed_in	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STAU1 in their description or question text

No additional research found