| Gene Symbol | HK1 |
| Full Name | Hexokinase 1 |
| Chromosome | 10p11.2 |
| Protein Type | Enzyme |
| Function | Hexokinase 1 (HK1) is the first enzyme in glycolysis, catalyzing the phosphorylation of glucose to glucose-6-phosphate using ATP. |
| Amino Acids | 908 aa |
| Pathways | Erk Signaling, Glycolysis, Mapk |
| UniProt ID | P19367 |
| NCBI Gene ID | 3099 |
| Ensembl ID | ENSG00000156515 |
| OMIM | 142600 |
| GeneCards | HK1 |
| Human Protein Atlas | HK1 |
| N-terminal glucose-binding domain | High-affinity binding (Km ~0.1 mM) |
| C-terminal catalytic domain | ATP binding and phosphate transfer |
| Associated Diseases | Als, Alzheimer, Cancer, Tumor |
| Known Drugs/Compounds | aducanumab |
| Interactions | AGING, AKT, AMPK, APOPTOSIS, CANCER, FASN |
| SciDEX Hypotheses | Glycan Pattern Disruption via Metabolic Interventi |
| KG Connections | 149 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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