Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about OX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| sleep maintenance | involved_in | process | 0.80 |
| OX2 | interacts_with | protein | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HCRT | activates | gene | 0.95 |
| vornorexant | inhibits | drug | 0.95 |
| vornorexant | binds | drug | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v | 0.777 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th | 0.695 | neurodegeneration | Neuroinflammation resolution mechanisms |
| ALOX15 Inhibition Combined with Selenium Augmentation for Sy | 0.580 | - | Ferroptosis in ALS and motor neuron dise |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Bioinformatics analysis and hub gene identification | exploratory | Alzheimer's disease | 0.800 | 0.00 | computational analysis of tran | proposed | N/A |
| s:** - ALOX15 overexpression in healthy astrocytes should be protectiv | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924] | Cai W, Liu L, Shi X, Liu Y, Wang J, Fang | Circulation | 2023 | 1 |
| Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829] | Tong J, Lan XT, Zhang Z, Liu Y, Sun DY, | Acta Pharmacol Sin | 2023 | 1 |
| CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859] | Zhang H, Deng T, Liu R, Ning T, Yang H, | Mol Cancer | 2020 | 1 |
| Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102] | Zhao Y, Bhattacharjee S, Jones BM, Hill | Mol Neurobiol | 2014 | 1 |
| ALOX15 exerts tumor-suppressive role in head and neck squamous cell carcinoma vi [PMID:41820595] | Liu A, Zhang X, Li R, Zhang Y, Yang Z, Z | Functional & integrative genom | 2026 | 0 |
| Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 C [PMID:41589658] | Hou G, Luan J, Xu X, Qin J, Ma S et al. | Adv Sci (Weinh) | 2026 | 0 |
| Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892] | Lin D, Li K, Kuang W, Chen Z, Zhang M | World J Mens Health | 2026 | 0 |
| Sanhua essential oil exerts antidepressant effects in breast cancer-related depr [PMID:41722126] | Li X, Xu Z, Ju P, Dong M, Wang Y et al. | Phytomedicine | 2026 | 0 |
| Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Develop [PMID:41750540] | Man GCW, Borchert A, Zhang T, Hung SW, K | Antioxidants (Basel, Switzerla | 2026 | 0 |
| ALOX15-Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq-P [PMID:41847922] | Hilman A, Ishii Y, Wijatniko BD, Rini DM | FASEB journal : official publi | 2026 | 0 |
| Cigarette Smoke Exacerbates Pressure Overload-Induced Right Ventricular Dysfunct [PMID:41746293] | Zhou L, Bai Q, Shi R, Zeng X, Deng J, Lu | FASEB journal : official publi | 2026 | 0 |
| FGF21 promotes the resolution of inflammation through the ALOX15/SPM pathway in [PMID:41913238] | Chenxi Shen; Yuan Cao; Jinling Wei; Xiny | Respiratory research | 2026 | 0 |
| Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic do [PMID:39882747] | Deng S, Cao H, Li T, Wang X, Meng J, Zen | Gut microbes | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early [PMID:39362839] | Yang X, Chen H, Shen W, Chen Y, Lin Z, Z | Nature communications | 2024 | 0 |
| Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer ba [PMID:37469520] | Shen L, Huang H, Li J, Chen W, Yao Y, Hu | Frontiers in immunology | 2023 | 0 |
| A survey of human brain transcriptome diversity at the single cell level. [PMID:26060301] | ["Darmanis S", "Sloan S", "Zhang Y", "En | Proceedings of the National Ac | 2015 | 0 |
| Exploring sRNA-mediated gene silencing mechanisms using artificial small RNAs de [PMID:23393193] | ["Park H", "Bak G", "Kim S", "Lee Y"] | Nucleic acids research | 2013 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning OX1 in their description or question text
No additional research found