cell 851 words KG: ent-gene-f5d77c22
Contents

GABA-A Alpha2 Neurons

🔬 Protein Info
Gene SymbolGABA
Full NameA Alpha2 Neurons
Chromosome12p12.3
Functionis a hallmark of neurodegeneration.
Primary Expressionhippocampus, cortex, cerebellum, thalamus, hypothalamus
Amino Acids602 aa
Exons14
PathwaysGABAergic Signaling
GeneCardsGABA
Human Protein AtlasGABA
AmygdalaHigh density in the basolateral amygdala, particularly in intercalated cell masses
HippocampusProminent expression in CA1 pyramidal neurons and dentate gyrus
CortexLayer-specific expression, strongest in layers II/III and V
Basal GangliaExpression in striatum and globus pallidus
ThalamusModerate expression in relay nuclei
Associated DiseasesAls, Alzheimer, Alzheimer's disease
Known Drugs/Compoundsrapamycin
InteractionsABCA7, ACTB, Actin, Akt, AKT, AKT1
KG Connections1369 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (5)

Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
...
Score: 0.68

Related Analyses (11)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived

Related Experiments (3)

Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Non-Dopaminergic Neurotransmitter Degeneration in PD - Exper
clinical · proposed · Score: 0.40

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