gene 929 words KG: GABRG2
Contents

GABRG2 — GABA-A Receptor Gamma2 Subunit

🧬 Gene Info
Gene SymbolGABRG2
Full NameGABA-A Receptor Gamma2 Subunit
Chromosome5
Protein TypeChannel
FunctionThe GABA-A receptor is a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the central nervous system.
Subcellular Localization, and trafficking of the receptor
UniProt ID[P18507](https://www.uniprot.org/uniprotkb/P18507/entry)
Ensembl IDENSG00000102265
GeneCardsGABRG2
Human Protein AtlasGABRG2
AmygdalaModerate to high expression
CerebellumHigh expression in Purkinje cells
Associated DiseasesAging, Als, Blindness, epilepsy
InteractionsApp, GABRA1, GABRA5, GRIA1, GRIN2A, KCNH2
KG Connections47 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (6)

Clinical characterization of GABRA1/GABRG2 microdeletion pat
clinical · proposed · Score: 0.95
Phenobarbital treatment efficacy study
clinical · proposed · Score: 0.90
Gabra1+/-/Gabrg2+/- mouse model characterization
validation · proposed · Score: 0.90
Optic nerve myelination analysis
exploratory · proposed · Score: 0.88
GABAA receptor subunit expression analysis
exploratory · proposed · Score: 0.85

See Also (5)

Genes
index · KG edge: associated_with
GABRA1 Gene
gene · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

GABRG2 associated_with GABRA1
GABRA1 associated_with GABRG2
GABRG2 associated_with Blindness
GABRA1 co_discussed GABRG2
GABRA1 interacts_with GABRG2
GABRG2 inhibits Rb
GABRG2 implicated_in BLINDNESS
GABRG2 associated_with epilepsy
GABRG2 causes Blindness
GABRG2 causes Optic Atrophy

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