protein

CAVEOLIN-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAVEOLIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

26Outgoing

12Incoming

0Experiments

0Debates

Summary

Caveolin-1 is a 22 kDa scaffolding protein essential for caveolae formation, lipid raft organization, and neuronal signaling, with key roles in Alzheimer's disease and Parkinson's disease pathogenesis

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🔬 Protein Info

Gene Symbol	CAVEOLIN
Function	The CAV1 gene encodes caveolin-1, a 22-24 kDa integral membrane protein that serves as the principal structural component of caveolae.
GeneCards	CAVEOLIN
Human Protein Atlas	CAVEOLIN
Associated Diseases	cancer
Interactions	AGO2, CAV1, MFSD2A, PRKACA
KG Connections	38 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

CAVEOLIN-1 Protein (CAV1)

protein · 796 words

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Pathway Diagram

graph TD
    CAVEOLIN_1["CAVEOLIN-1"]
    ZO1["ZO1"]
    CAVEOLIN_1 -->|"regulates"| ZO1
    mitochondrial_dysfunction["mitochondrial dysfunction"]
    CAVEOLIN_1 -->|"activates"| mitochondrial_dysfunction
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    CAVEOLIN_1 -->|"regulates"| BLOOD_BRAIN_BARRIER
    Endocytosis["Endocytosis"]
    CAVEOLIN_1 -->|"regulates"| Endocytosis
    Endothelial_Cell["Endothelial Cell"]
    CAVEOLIN_1 -->|"regulates"| Endothelial_Cell
    ENDOTHELIAL["ENDOTHELIAL"]
    CAVEOLIN_1 -->|"regulates"| ENDOTHELIAL
    ISCHEMIC["ISCHEMIC"]
    CAVEOLIN_1 -->|"regulates"| ISCHEMIC
    ISCHEMIC_STROKE["ISCHEMIC STROKE"]
    CAVEOLIN_1 -->|"regulates"| ISCHEMIC_STROKE
    ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"]
    CAVEOLIN_1 -->|"regulates"| ENDOTHELIAL_CELLS
    STEM_CELLS["STEM CELLS"]
    CAVEOLIN_1 -->|"regulates"| STEM_CELLS
    EXTRACELLULAR_VESICLES["EXTRACELLULAR VESICLES"]
    CAVEOLIN_1 -->|"regulates"| EXTRACELLULAR_VESICLES
    ENDOTHELIAL["ENDOTHELIAL"]
    CAVEOLIN_1 -->|"associated with"| ENDOTHELIAL
    Cholesterol["Cholesterol"]
    CAVEOLIN_1 -->|"causes"| Cholesterol
    mitochondrial_dysfunction["mitochondrial dysfunction"]
    CAVEOLIN_1 -->|"causes"| mitochondrial_dysfunction
    cancer["cancer"]
    CAVEOLIN_1 -->|"associated with"| cancer
    TUMOR["TUMOR"]
    CAVEOLIN_1 -->|"expressed in"| TUMOR
    METASTASIS["METASTASIS"]
    CAVEOLIN_1 -->|"expressed in"| METASTASIS
    Invasion["Invasion"]
    CAVEOLIN_1 -->|"expressed in"| Invasion
    GLIOBLASTOMA["GLIOBLASTOMA"]
    CAVEOLIN_1 -->|"causes"| GLIOBLASTOMA
    TUMOR["TUMOR"]
    CAVEOLIN_1 -->|"interacts with"| TUMOR
    cancer["cancer"]
    CAVEOLIN_1 -->|"interacts with"| cancer
    mitophagy["mitophagy"]
    CAVEOLIN_1 -->|"interacts with"| mitophagy
    DIABETES["DIABETES"]
    CAVEOLIN_1 -->|"interacts with"| DIABETES
    Neuron["Neuron"]
    CAVEOLIN_1 -->|"interacts with"| Neuron
    Prion["Prion"]
    CAVEOLIN_1 -->|"regulates"| Prion
    AMYLOID["AMYLOID"]
    CAVEOLIN_1 -->|"regulates"| AMYLOID
    AMYLOID_BETA["AMYLOID BETA"]
    CAVEOLIN_1 -->|"regulates"| AMYLOID_BETA
    inflammation["inflammation"]
    CAVEOLIN_1 -->|"regulates"| inflammation
    ISCHEMIA["ISCHEMIA"]
    CAVEOLIN_1 -->|"regulates"| ISCHEMIA
    inflammation["inflammation"]
    CAVEOLIN_1 -->|"associated with"| inflammation

Outgoing (26)

Target	Relation	Type	Str
ZO1	regulates	protein	0.60
Endocytosis	regulates	pathway	0.50
Endothelial Cell	regulates	cell_type	0.50
ENDOTHELIAL	regulates	concept	0.50
ISCHEMIC	regulates	concept	0.50
ISCHEMIC STROKE	regulates	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
Cholesterol	causes	pathway	0.50
cancer	associated_with	disease	0.50
TUMOR	expressed_in	disease	0.50
Invasion	expressed_in	pathway	0.50
GLIOBLASTOMA	causes	gene	0.50
TUMOR	interacts_with	disease	0.50
cancer	interacts_with	disease	0.50
mitophagy	interacts_with	pathway	0.50
DIABETES	interacts_with	disease	0.50
Neuron	interacts_with	cell_type	0.50
Prion	regulates	protein	0.50
AMYLOID	regulates	gene	0.50
AMYLOID BETA	regulates	concept	0.50
inflammation	regulates	pathway	0.50
ISCHEMIA	regulates	disease	0.50
inflammation	associated_with	pathway	0.50

Incoming (12)

Source	Relation	Type	Str
STROKE	regulates	gene	0.50
CLAUDIN-5	regulates	protein	0.50
RHOA	associated_with	gene	0.50
CAV1	activates	gene	0.50
PRKACA	activates	gene	0.50
CAV1	expressed_in	gene	0.50
UBIQUITIN	causes	protein	0.50
CAV1	interacts_with	gene	0.50
AGO2	interacts_with	protein	0.50
MITOCHONDRIA	interacts_with	cell_type	0.50
MITOCHONDRIA	activates	cell_type	0.50
MFSD2A	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CAVEOLIN-1 in their description or question text

No additional research found