concept

SYSTEMIC INFLAMMATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYSTEMIC INFLAMMATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

53Connections

0Hypotheses

1Analyses

13Outgoing

40Incoming

0Experiments

1Debates

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💡 Concept Info

Name	SYSTEMIC INFLAMMATION

Pathway Diagram

graph TD
    SYSTEMIC_INFLAMMATION["SYSTEMIC INFLAMMATION"]
    SYSTEMIC_INFLAMMATION -->|"contributes to"| Neuroinflammation["Neuroinflammation"]
    SYSTEMIC_INFLAMMATION -->|"risk_factor_for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    SYSTEMIC_INFLAMMATION -->|"causes"| Apathy["Apathy"]
    SYSTEMIC_INFLAMMATION -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    SYSTEMIC_INFLAMMATION -->|"regulates"| glial_activation["glial activation"]
    Acute_Sleep_Deprivation["Acute Sleep Deprivation"] -->|"causes"| SYSTEMIC_INFLAMMATION
    Periodontitis["Periodontitis"] -->|"causes"| SYSTEMIC_INFLAMMATION
    TNF__["TNF-Alpha"] -->|"mediates"| SYSTEMIC_INFLAMMATION
    IL_6["IL-6"] -->|"promotes"| SYSTEMIC_INFLAMMATION
    STING["STING"] -->|"promotes"| SYSTEMIC_INFLAMMATION
    senescent_fibroblasts["senescent fibroblasts"] -->|"promotes"| SYSTEMIC_INFLAMMATION
    STING_activation["STING activation"] -->|"promotes"| SYSTEMIC_INFLAMMATION
    Ginkgetin["Ginkgetin"] -.prevents.-> SYSTEMIC_INFLAMMATION

Outgoing (13)

Target	Relation	Type	Str
Neuroinflammation	causes	process	0.95
Neuroinflammation	contributes_to	process	0.90
Neuroinflammation	promotes	process	0.90
Alzheimer'S Disease	risk_factor_for	disease	0.85
Alzheimer's Disease	risk_factor_for	disease	0.85
Apathy	causes	phenotype	0.85
Neurodegeneration Progression	associated_with	process	0.80
neurodegeneration	associated_with	disease	0.80
Neurodegeneration	contributes_to	process	0.80
microglial epigenetic reprogramming	causes	mechanism	0.70
Neurodegeneration	promotes	process	0.70
Alzheimer's disease	associated_with	disease	0.70
glial activation	regulates	process	0.70

Incoming (40)

Source	Relation	Type	Str
Periodontitis	causes	disease	0.95
Savi	associated_with	disease	0.95
Neuropathic Pain	causes	disease	0.95
Acute Sleep Deprivation	causes	process	0.95
Neuropathic pain	associated_with	disease	0.90
IL-6	promotes	protein	0.90
CSF3	contributes_to	gene	0.90
TNF-Α	mediates	protein	0.90
IL13	contributes_to	gene	0.90
Macrophages	mediates	cell_type	0.90
Ginkgetin	prevents	drug	0.90
STING	promotes	protein	0.90
senescent fibroblasts	promotes	cell_type	0.90
STING activation	promotes	process	0.90
SIRT1	inhibits	gene	0.89
macrophages	mediates	cell_type	0.88
Oxidative Stress	associated_with	process	0.88
Dysbiotic Oral Bacteria	contributes_to	biomarker	0.88
riboflavin	suppresses	compound	0.85
CGAS-STING pathway	promotes	pathway	0.85
USP22 Deficiency	causes	phenotype	0.85
USP22	inhibits	gene	0.85
Dysbiotic Oral Bacteria	promotes	cell_type	0.85
IL-1	mediates	protein	0.85
IL-6	mediates	protein	0.85
STING	mediates	protein	0.85
Gut Microbiota	modulates	cell_type	0.85
IL13	upregulates	gene	0.85
CSF3	upregulates	gene	0.85
Gut Microbiota Dysbiosis	contributes_to	process	0.85
acute sleep deprivation	exacerbates	process	0.80
exercise	inhibits	phenotype	0.80
Myeloid-Immune Signaling Pathways	therapeutic_target	pathway	0.80
Artemisia annua extracts	suppresses	compound	0.80
Metabolic Disturbances	causes	process	0.80
HSPA1A	associated_with	protein	0.80
extracellular vesicles	promotes	process	0.78
lipid metabolism dysregulation	associated_with	process	0.78
Lactobacillus	protects_against	cell_type	0.75
Enterobacter	contributes_to	cell_type	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Synaptic pruning by microglia in neurodegeneration

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the role of microglial synaptic pruning in Alzheimer's disease and other

closed · Rounds: 4 · Score: 0.68 · 2026-04-22

Related Research

Hypotheses and analyses mentioning SYSTEMIC INFLAMMATION in their description or question text

No additional research found