concept

PSME2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSME2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

0Hypotheses

0Analyses

28Outgoing

4Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PSME2
Key Genes/Proteins	AND, CANCER, DNA
Related Diseases	Als, ALS, Cancer, Cell Invasion, Cell Migration
Related Pathways	DNA Methylation, epigenetic regulation

Pathway Diagram

graph TD
    PSME2["PSME2"]
    PSME2 -.biomarker for.-> M1_Macrophage_Infiltration["M1 Macrophage Infiltration"]
    PSME2 -->|"inhibits"| Tumor_Proliferation["Tumor Proliferation"]
    PSME2 -->|"inhibits"| Cell_Migration["Cell Migration"]
    PSME2 -->|"inhibits"| Cell_Invasion["Cell Invasion"]
    PSME2 -->|"correlates_with"| DNA_Methylation["DNA Methylation"]
    PSME2 -->|"activates"| Als["Als"]
    PSME2 -->|"expressed in"| Cancer["Cancer"]
    PSME2 -->|"inhibits"| Tumor["Tumor"]
    Irinotecan["Irinotecan"] -->|"activates"| PSME2
    AND["AND"] -->|"expressed in"| PSME2

Outgoing (28)

Target	Relation	Type	Str
M1 Macrophage Infiltration	biomarker_for	process	0.95
Cell Invasion	inhibits	phenotype	0.92
Cell Migration	inhibits	phenotype	0.92
Tumor Proliferation	inhibits	phenotype	0.92
Osteosarcoma Malignant Phenotypes	inhibits	phenotype	0.92
Tumor Invasion	suppresses	phenotype	0.92
Tumor Migration	suppresses	phenotype	0.92
Osteosarcoma	associated_with	disease	0.90
Cancer Progression	associated_with	process	0.88
Genomic Instability	correlates_with	process	0.85
Dna Methylation	associated_with	process	0.85
Dna Repair	associated_with	process	0.85
DNA Methylation	correlates_with	mechanism	0.80
Als	activates	disease	0.65
Cancer	expressed_in	disease	0.65
ALS	activates	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	biomarker_for	disease	0.65
macrophages	expressed_in	cell_type	0.60
epigenetic regulation	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Macrophage	biomarker_for	cell_type	0.60
AND	expressed_in	gene	0.60
DNA	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
Proteasome	activates	pathway	0.60
Macrophage	expressed_in	cell_type	0.55

Incoming (4)

Source	Relation	Type	Str
Irinotecan	activates	drug	0.85
DNA	associated_with	gene	0.60
DNA	expressed_in	gene	0.60
AND	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PSME2 in their description or question text

No additional research found