Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about dCas9-Tet1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| DNA methylation | associated_with | phenotype | 0.90 |
| BDNF | activates | gene | 0.90 |
| MyoD | activates | gene | 0.90 |
| hypermethylated neuronal genes | targets | gene | 0.70 |
| youthful gene expression patterns | restores | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Targeted DNA Demethylation at the Klotho Locus via dCas9-TET | 0.510 | neurodegeneration | epigenetic reprogramming aging neurons |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-10 | 7 hypotheses Top: 0.700
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-21
closed · Rounds: 0 · Score: 0.48 · 2026-04-21
closed · Rounds: 0 · Score: 0.51 · 2026-04-21
closed · Rounds: 4 · Score: 0.73 · 2026-04-21
Hypotheses and analyses mentioning dCas9-Tet1 in their description or question text
No additional research found