pathway

Dna Methylation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Dna Methylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

889Connections

8Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Dna Methylation is a biological pathway involved in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 496 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Dna Methylation
Key Genes/Proteins	ABCB1, ABCG1, ACE, Actin, ADRA1A, ADRA1B
Related Diseases	aging, Aging, Als
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DNA Methylation

entity · 1249 words

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Pathway Diagram

graph TD
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Wnt["Wnt"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Epigenetic["Epigenetic"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Mtor["Mtor"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Akt["Akt"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Pi3K["Pi3K"]
    IDH1["IDH1"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    VEGFA["VEGFA"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    MDM4["MDM4"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    APOB["APOB"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    style Dna_Methylation fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (141)

Target	Relation	Type	Str
Neurological Disorders	involved_in	disease	0.95
Human Aging	biomarker_for	process	0.95
mammalian brain development	involved_in	process	0.95
Neurodegenerative Diseases	involved_in	disease	0.95
Progression Of Neurological Disorders	contributes_to	phenotype	0.90
PI3K/AKT/mTOR	regulates	pathway	0.90
Therapy Resistance	contributes_to	phenotype	0.90
BRAIN DEVELOPMENT	involved_in	entity	0.90
Mammalian Brain Development	mediates	process	0.90
Thyroid Cancer	involved_in	disease	0.90
Mitochondrial Dysfunction Gene Expression	regulates	process	0.90
learning and memory	regulates	phenotype	0.90
frontal cortex	expressed_in	brain_region	0.90
CRHBP	regulates	gene	0.85
Gene Expression	regulates	process	0.85
Primary Open Angle Glaucoma	involved_in	disease	0.85
CORTEX	expressed_in	entity	0.85
synaptic plasticity	involved_in	process	0.85
CRH	regulates	gene	0.85
CRHR1	regulates	gene	0.85
Clear-Cell Renal Cell Carcinoma	biomarker_for	disease	0.85
Clear-Cell Renal Cell Carcinoma	involved_in	disease	0.85
Post-Stroke Depression	involved_in	disease	0.85
HPA axis	regulates	pathway	0.80
Hypersexual Disorder	biomarker_for	disease	0.80
Gene expression	regulates	process	0.80
neurological disorders	associated_with	disease	0.80
Disease Prevention	involved_in	process	0.75
Central Precocious Puberty	mediates	disease	0.75
Forensics	involved_in	process	0.70
gene transcription	regulates	process	0.70
Parkinson's Disease	regulates	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
P53	processes	gene	0.65
NRF2	processes	gene	0.65
UBIQUITIN	activates	gene	0.65
AGING	interacts_with	phenotype	0.65
KEAP1	processes	gene	0.65
MTOR	processes	gene	0.65
PI3K	processes	gene	0.65
HTT	interacts_with	gene	0.60
STING	interacts_with	gene	0.60
T CELLS	regulates	cell_type	0.60
T CELL	regulates	cell_type	0.60
NEURODEGENERATION	regulates	disease	0.60
SYNAPTIC PLASTICITY	protects_against	phenotype	0.60
P300	regulates	gene	0.60
NEURONS	treats	cell_type	0.60
AUTOPHAGY	inhibits	phenotype	0.60
TUMOR	expressed_in	disease	0.60

Incoming (748)

Source	Relation	Type	Str
Als	regulates	disease	1.00
DNA	inhibits	gene	1.00
DNA	activates	gene	1.00
Als	associated_with	disease	1.00
Cancer	associated_with	disease	1.00
CANCER	associated_with	gene	1.00
CANCER	regulates	gene	1.00
Cancer	regulates	disease	1.00
DNA	associated_with	gene	1.00
GENES	associated_with	gene	1.00
DNA	regulates	gene	1.00
GENES	regulates	gene	1.00
Als	therapeutic_target	disease	1.00
entities-dna-methylation	describes	wiki	1.00
Cancer	expressed_in	disease	1.00
INFLAMMATION	regulates	gene	1.00
Inflammation	regulates	disease	1.00
Als	treats	disease	1.00
CANCER	expressed_in	gene	1.00
APOPTOSIS	regulates	gene	1.00
Gut Microbiota	modulates	process	0.95
dCas9-Dnmt3a	associated_with	protein	0.90
dCas9-Tet1	associated_with	protein	0.90
28798132	distinguishes and marks	paper	0.90
28798132	distinguishes	paper	0.90
DNA	expressed_in	gene	0.90
Als	expressed_in	disease	0.90
Cancer	therapeutic_target	disease	0.90
GENES	therapeutic_target	gene	0.90
Aging	associated_with	disease	0.90
Tumor	therapeutic_target	disease	0.90
Tumor	regulates	disease	0.90
PSME2	associated_with	gene	0.85
2-hydroxyglutarate	promotes	compound	0.85
HSV-gB	modulates	protein	0.80
PSME2	correlates_with	gene	0.80
OVERVIEW	treats	gene	0.80
ALZHEIMER'S DISEASE	associated_with	gene	0.80
Inflammation	associated_with	disease	0.80
Tumor	expressed_in	disease	0.80
INFLAMMATION	associated_with	gene	0.80
AGING	associated_with	gene	0.80
Tumor	associated_with	disease	0.80
AUTOPHAGY	regulates	gene	0.80
CANCER	inhibits	gene	0.80
GENES	inhibits	gene	0.80
DNA	therapeutic_target	gene	0.80
DNA	causes	gene	0.80
ALZHEIMER	associated_with	gene	0.80
OXIDATIVE STRESS	regulates	gene	0.80

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DNA Methylation Clock Drift at Glial Promoters	0.480	neurodegeneration	Comparative epigenetic signatures: DNA m
TET Enzyme Enhancement to Prevent Aberrant DNA Methylation	0.350	neurodegeneration	Comparative epigenetic signatures across
protective chromatin remodeling defines the therapeutic wind	0.345	neurodegeneration	Are DNA methylation changes in neurodege
age-linked CpG drift is the actionable driver in: Are DNA me	0.344	neurodegeneration	Are DNA methylation changes in neurodege
age-linked CpG drift is the actionable driver in: Are age-re	0.344	neurodegeneration	Are age-related DNA methylation changes

ATAC-seq accessibility separates causal from compensatory st	0.342	neurodegeneration	Are DNA methylation changes in neurodege
ATAC-seq accessibility separates causal from compensatory st	0.327	neurodegeneration	Are age-related DNA methylation changes
protective chromatin remodeling defines the therapeutic wind	0.326	neurodegeneration	Are age-related DNA methylation changes

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Genome-wide methylation profiles reveal quantitative views of human aging rates. [PMID:23177740]	Hannum G, Guinney J, Zhao L, Zhang L, Hu	Mol Cell	2013	1
DNA methylation and prediction of biological age. [PMID:41602542]	Chen Y, Cheng X, Ji S	Front Mol Biosci	2025	0
Causality-enriched epigenetic age uncouples damage and adaptation. [PMID:38243142]	Ying K, Liu H, Tarkhov AE	Nat Aging	2024	0
PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction [PMID:38320550]	Chappidi, Quail, Doll, Vogel, Aleksandro	Cell	2024	0
DNA-Origami-Armored DNA Condensates. [PMID:39075031]	Yamashita, Sato, Suzuki, Ishikawa, Takin	Chembiochem : a European journ	2024	0
PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction [PMID:38320550]	Chappidi Nagaraja; Quail Thomas; Doll Si	Cell	2024	0
Causality-enriched epigenetic age uncouples damage and adaptation. [PMID:38243142]	Ying K, Liu H, Tarkhov AE, Sadler MC, Lu	Nature aging	2024	0
DNA-Origami-Armored DNA Condensates. [PMID:39075031]	Unknown	Chembiochem : a European journ	2024	0
Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive ne [PMID:36931244]	Khazaei Sima; Chen Carol C L; Andrade Au	Cell	2023	0
Neurodegeneration and epigenetics: A review. [PMID:37344098]	Ghosh P, Saadat A	Neurologia (Engl Ed)	2023	0
Regulation of Human DNA Primase-Polymerase PrimPol. [PMID:37758313]	Boldinova, Makarova	Biochemistry. Biokhimiia	2023	0
Global identification of SWI/SNF targets reveals compensation by EP400. [PMID:37922899]	Martin BJE, Ablondi EF, Goglia C	Cell	2023	0
Regulation of Human DNA Primase-Polymerase PrimPol. [PMID:37758313]	Unknown	Biochemistry. Biokhimiia	2023	0
Neurodegeneration and epigenetics: A review. [PMID:37344098]	["Ghosh P", "Saadat A"]	Neurologia	2023	0
Site-specific mitochondrial dysfunction in neurodegeneration. [PMID:35182728]	Vodičková A, Koren SA, Wojtovich AP	Mitochondrion	2022	0
Chromatin accessibility profiling by ATAC-seq. [PMID:35478247]	Grandi Fiorella C; Modi Hailey; Kampman	Nature protocols	2022	0
DNA damage and repair in age-related inflammation. [PMID:35831609]	Zhao Yang; Simon Matthew; Seluanov Andre	Nature reviews. Immunology	2022	0
Bone remodeling: an operational process ensuring survival and bone mechanical co [PMID:35851054]	Bolamperti Simona; Villa Isabella; Rubin	Bone research	2022	0
Chromatin accessibility profiling by ATAC-seq. [PMID:35478247]	Unknown	Nature protocols	2022	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Dna Methylation in their description or question text