| Gene Symbol | DDX3X |
| Aliases | DDX3XPROTEIN |
| Chromosome | Xp11.4 |
| Function | is an ATP-dependent RNA helicase that belongs to the DEAD-box family of RNA helicases. |
| Molecular Weight | 73 kDa |
| Amino Acids | 662 aa |
| Exons | 17 |
| Pathways | NF-κB, Wnt |
| GeneCards | DDX3X |
| Human Protein Atlas | DDX3X |
| Multiple phosphorylation sites | Serine/threonine phosphorylation regulates DDX3X activity and interactions |
| Nuclear localization signal | Enables nucleocytoplasmic shuttling |
| Translation initiation | DDX3X assists both cap-dependent and cap-independent (IRES-mediated) translation initiation by unwinding secondary structures in the 5' UTR[@bottomley2006] |
| RNA splicing | Modulates alternative splicing by interacting with spliceosome components |
| RNA transport | Facilitates mRNA nuclear export through interactions with exportin-1 (XPO1/CRM1) |
| Associated Diseases | Als, Alzheimer, Autism, depression, neurodegeneration |
| Interactions | ALS, AMYOTROPHIC LATERAL SCLEROSIS, C9ORF72, ERK1/2, G3BP1, IL-1 |
| KG Connections | 91 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!