gene 716 words KG: CRY2
Contents

CRY2 Gene

🧬 Gene Info
Gene SymbolCRY2
Full NameCryptochrome Circadian Regulator 2
Chromosome4p16.3
FunctionThe CRY2 gene encodes Cryptochrome Circadian Regulator 2, a key component of the mammalian circadian clock.
Molecular Weight66 kDa
PathwaysAmyloid, Cholesterol, Circadian Rhythm, Lipid Metabolism, Mtor
UniProt IDQ96T44
NCBI Gene ID1399
Ensembl IDENSG00000116771
OMIM604961
GeneCardsCRY2
Human Protein AtlasCRY2
Photolyase homology region (PHR)the FAD-binding domain
Tail domaininvolved in protein interactions
DAS motifdouble Asp residues for FAD binding
Associated DiseasesAls, Depression, Stroke
InteractionsActin, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APP
KG Connections112 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Circadian Clock-Autophagy Synchronization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Axonal RNA Transport Reconstitution
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (9)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

Circadian gene expression effects of SD vs ketamine
exploratory · proposed · Score: 0.95
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90

See Also (11)

Astrocytes
cell · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator
gene · KG edge: expressed_in
BDNF Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

PER1 regulates CRY2
CRY1 regulates CRY2
CRY2 regulates PER2
CRY2 regulates BMAL1
CRY1 expressed_in CRY2
CRY1 associated_with CRY2
CRY2 regulates CLOCK
CRY2 associated_with BMAL1
PER3 expressed_in CRY2
PER1 expressed_in CRY2

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