gene 667 words KG: CHRNE
Contents

CHRNE Gene

🧬 Gene Info
Gene SymbolCHRNE
Full NameCholinergic Receptor Nicotinic Epsilon Subunit
Chromosome17p13.2
FunctionCHRNE encodes the epsilon subunit of nicotinic receptors at the NMJ.
Primary Expressionthe brain and play roles in cognitive function, attention, and motor control
PathwaysWnt
UniProt ID[P30530](https://www.uniprot.org/uniprotkb/P30530/entry)
GeneCardsCHRNE
Human Protein AtlasCHRNE
Associated DiseasesAls, Alzheimer, Ms
InteractionsASTROCYTE, CASS4, Cytokine, CYTOKINES, GENES, IL13
KG Connections87 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
adra2b Gene
gene · KG edge: expressed_in
BIN1 — Bridging Integrator 1
gene · KG edge: associated_with
CASS4 — Cas Scaffold Protein Family Member 4
gene · KG edge: associated_with

Knowledge Graph (12 edges)

APP associated_with CHRNE
NDUFAF7 associated_with CHRNE
SHARPIN associated_with CHRNE
APOE associated_with CHRNE
PLCG2 associated_with CHRNE
CHRM4 expressed_in CHRNE
MYO7A activates CHRNE
GRM2 expressed_in CHRNE
WNT1 activates CHRNE
CRH expressed_in CHRNE

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