| Gene Symbol | CHEK1 |
| Full Name | Checkpoint Kinase 1 |
| Chromosome | 11q24.2 |
| Protein Type | Serine/Threonine Kinase |
| Function | CHEK1 (Checkpoint Kinase 1) is a serine/threonine kinase that plays a central role in the DNA damage response (DDR). |
| Molecular Weight | 56 kDa |
| Amino Acids | 476 aa |
| Pathways | Akt, Pi3K |
| UniProt ID | CHEK1 |
| Ensembl ID | ENSG00000149554 |
| OMIM | 604603 |
| GeneCards | CHEK1 |
| Human Protein Atlas | CHEK1 |
| DNA Damage Checkpoint | Halts cell cycle progression for DNA repair |
| Replication Fork Stability | Prevents replication fork collapse |
| Associated Diseases | Als, Ataxia, Infection |
| Known Drugs/Compounds | Thiabendazole |
| Interactions | CANCER, CDK1, CDK2, DNA, Egfr, EGFR |
| KG Connections | 71 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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