concept

CASPASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

809Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CASPASE

Pathway Diagram

graph TD
    CASPASE["CASPASE"]
    style CASPASE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CASPASE -->|"activates"| PANoptosis["PANoptosis"]
    CASPASE -->|"cleaves"| GSDME([GSDME])
    CASPASE -->|"activates"| neurodegeneration["neurodegeneration"]
    CASPASE -->|"activates"| IL1B([IL1B])
    CASPASE -->|"regulates"| Fibrosis["Fibrosis"]
    CASPASE -->|"interacts"| Cancer["Cancer"]
    CASPASE -->|"interacts"| Als["Als"]
    CASPASE -.->|"inhibits"| Aging["Aging"]
    RIPK1([RIPK1]) -->|"interacts"| CASPASE
    PPARG([PPARG]) -->|"interacts"| CASPASE
    WNT([WNT]) -->|"regulates"| CASPASE
    TFEB([TFEB]) -->|"interacts"| CASPASE
    CFTR([CFTR]) -->|"regulates"| CASPASE
    RICTOR([RICTOR]) -->|"interacts"| CASPASE
    ROS([ROS]) -->|"regulates"| CASPASE
    GRB2([GRB2]) -->|"interacts"| CASPASE
    HSP70([HSP70]) -->|"interacts"| CASPASE
    STAT3([STAT3]) -->|"interacts"| CASPASE

Outgoing (207)

Target	Relation	Type	Str
PANoptosis	activates	process	0.92
neurodegeneration	activates	process	0.70
Ischemia	activates	disease	0.60
Retinopathy	associated_with	disease	0.60
Cardiomyopathy	associated_with	disease	0.60
Diabetes	inhibits	disease	0.60
Cardiomyopathy	inhibits	disease	0.60
Neuroinflammation	activates	disease	0.60
Als	expressed_in	disease	0.60
Glioblastoma	activates	disease	0.60
Neuropathy	activates	disease	0.60
Alzheimer	inhibits	disease	0.60
Lymphoma	associated_with	disease	0.60
Stroke	regulates	disease	0.60
Huntington	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Lymphoma	activates	disease	0.60
Dementia	inhibits	disease	0.60
Depression	activates	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Anxiety	inhibits	disease	0.60
Cancer	expressed_in	disease	0.60
Parkinson	expressed_in	disease	0.60
Cancer	therapeutic_target	disease	0.60
Necroptosis	associated_with	disease	0.60
Vascular Dementia	therapeutic_target	disease	0.60
Obesity	regulates	disease	0.60
Diabetes	regulates	disease	0.60
Neurodegeneration	activates	disease	0.60
Als	regulates	disease	0.60
Cancer	inhibits	disease	0.60
Als	inhibits	disease	0.60
Pyroptosis	therapeutic_target	disease	0.60
Necroptosis	therapeutic_target	disease	0.60
Aging	inhibits	disease	0.60
Pyroptosis	degrades	disease	0.60
Pyroptosis	associated_with	disease	0.60
Cancer	associated_with	disease	0.60
Alzheimer	degrades	disease	0.60
Neurodegeneration	degrades	disease	0.60
Neuroinflammation	degrades	disease	0.60
Alzheimer	activates	disease	0.60
Als	degrades	disease	0.60
Fibrosis	regulates	disease	0.60
Ferroptosis	activates	disease	0.60
Aging	encodes	disease	0.60
Depression	interacts_with	disease	0.60
Lymphoma	phosphorylates	disease	0.60
Alzheimer	regulates	disease	0.60
Neuroinflammation	expressed_in	disease	0.60

Incoming (602)

Source	Relation	Type	Str
WT1	regulates	gene	0.60
LAMP1	regulates	gene	0.60
OCLN	regulates	gene	0.60
ATG14	associated_with	gene	0.60
VIMENTIN	regulates	gene	0.60
HDAC6	regulates	gene	0.60
TUBULIN	regulates	gene	0.60
MAP3K5	regulates	gene	0.60
TJP1	regulates	gene	0.60
GJA1	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
H2AX	associated_with	gene	0.60
RAC1	regulates	gene	0.60
BECN1	associated_with	gene	0.60
STING	activates	gene	0.60
CD68	expressed_in	gene	0.60
RNA	activates	gene	0.60
ANXA1	expressed_in	gene	0.60
CGAS-STING	activates	gene	0.60
AKT	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
CX43	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
KLK7	activates	gene	0.60
VEGF	associated_with	gene	0.60
AKT	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
HO-1	associated_with	gene	0.60
TLR	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
CREB	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
TAAR1	associated_with	gene	0.60
HUNTINGTON	expressed_in	gene	0.60
GAIN	causes	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
MYELIN	activates	gene	0.60
SYN2A	activates	gene	0.60
ELAVL3	activates	gene	0.60
BPMC	activates	gene	0.60
GAP43	activates	gene	0.60
ACHE	activates	gene	0.60
GFAP	activates	gene	0.60
MBP	activates	gene	0.60
AXON	activates	gene	0.60
MANF	activates	gene	0.60
AGING	inhibits	gene	0.60
NRF2	degrades	gene	0.60
VIM	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Caspase-2/3-mediated D421 truncation generates disease-speci	0.455	neurodegeneration	Which specific post-translational modifi
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea
Caspase-3 Cleavage of Tau Creates PS-Targeting Specificity	0.000	-	Does tau aggregation specifically cause

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASPASE in their description or question text

No additional research found