protein

CASPASE9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	CASPASE9
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	</strong></td><td>Mitochondria, Cytoplasm</td></tr>
Molecular Weight	46 kDa
Amino Acids	140 aa
GeneCards	CASPASE9
Human Protein Atlas	CASPASE9
N-terminal CARD domain	Protein-protein interactions with Apaf-1
Prodomain	~140 amino acids
Catalytic subunits	Large (p37) and small (p12) subunits after cleavage
Active tetramer	Two catalytic dimers
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Caspase-9

protein · 658 words

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Pathway Diagram

graph TD
    CASP9["CASP9 gene"]
    CASPASE9["CASPASE9 protein"]
    CYTC["Cytochrome c"]
    APAF1["APAF-1"]
    APOPTOSOME["Apoptosome complex"]
    CASP3["Caspase-3"]
    CASP7["Caspase-7"]
    MITO["Mitochondrial dysfunction"]
    OXSTRESS["Oxidative stress"]
    NEUROAPOP["Neuronal apoptosis"]
    ALZHEIMER["Alzheimer's disease"]
    PARKINSON["Parkinson's disease"]
    ALS["ALS"]
    XIAP["XIAP inhibitor"]
    BCL2["Bcl-2 family"]
    DNA_FRAG["DNA fragmentation"]
    
    CASP9 -->|"encodes"| CASPASE9
    MITO -->|"releases"| CYTC
    CYTC -->|"binds"| APAF1
    APAF1 -->|"forms"| APOPTOSOME
    APOPTOSOME -->|"activates"| CASPASE9
    CASPASE9 -->|"activates"| CASP3
    CASPASE9 -->|"activates"| CASP7
    CASP3 -->|"triggers"| DNA_FRAG
    CASP3 -->|"promotes"| NEUROAPOP
    OXSTRESS -->|"induces"| MITO
    NEUROAPOP -->|"contributes to"| ALZHEIMER
    NEUROAPOP -->|"contributes to"| PARKINSON
    NEUROAPOP -->|"contributes to"| ALS
    XIAP -->|"inhibits"| CASPASE9
    BCL2 -->|"prevents"| CYTC
    
    style CASPASE9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style XIAP fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style BCL2 fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style NEUROAPOP fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style ALZHEIMER fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
    style PARKINSON fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
    style ALS fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
    style CASP9 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style MITO fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style OXSTRESS fill:#3a1a1a,stroke:#ef5350,stroke-width:2px

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
CASP9	encodes	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASPASE9 in their description or question text

No additional research found