| Gene Symbol | CAPN1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | most tissues with highest levels in[@murphy1986]: |
| Molecular Weight | 80 kDa |
| Pathways | MAPK, mapk |
| Ensembl ID | ENSG00000021645 |
| GeneCards | CAPN1 |
| Human Protein Atlas | CAPN1 |
| Catalytic subunit (CAPN1, 80 kDa) | Contains the protease core with conserved cysteine protease domain |
| Regulatory subunit (CAPNS1, 28 kDa) | Required for enzyme stability, proper folding, and calcium sensitivity |
| Amyloid-beta effects | Aβ peptides trigger calcium dysregulation, leading to calpain overactivation |
| [Tau](/proteins/tau) cleavage | Calpain cleaves tau protein, generating toxic fragments that promote tau aggregation |
| Caspase activation | Calpain activates caspase-3, linking to apoptotic cell death |
| Associated Diseases | ALS, Alzheimer's disease, frontotemporal dementia |
| Interactions | AKT, AKT1, AND, BACE1, CDK5, DEPRESSION |
| KG Connections | 63 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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