protein 2,826 words KG: ABCA7PROTEIN
Contents

ABCA7 Protein

🔬 Protein Info
Gene SymbolABCA7
AliasesABCA7PROTEIN
Chromosome16p13.1
FunctionABCA7 encodes ATP-binding cassette transporter A7, a member of the ABC transporter family.
Primary Expressionimmune cells and the brain, where it plays important roles in lipid transport and cellular homeostasis
PathwaysCholesterol, Glycolysis, Immune Response, Lipid Metabolism, Nf-Κb
Ensembl IDENSG00000064687
GeneCardsABCA7
Human Protein AtlasABCA7
Associated Diseasesage-related macular degeneration, Als, Alzheimer, alzheimer_disease, Alzheimer's disease
InteractionsABCA1, ABCA4, ABCG1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections580 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (20)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (8)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 6 hypotheses
Neurodegeneration
disease · KG edge: implicated_in
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 5 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 5 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 5 hypotheses

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