Contents

SQSTM1 Protein (p62/Sequestosome-1)

🔬 Protein Info

Gene Symbol	SQSTM1
Full Name	SQSTM1 (p62/Sequestosome-1)
Chromosome	5q35.3.
Protein Type	Protein
Function	p62/SQSTM1 functions as: [@jones2021]
Molecular Weight	~62 kDa (hence p62)
Pathways	Adaptive Immunity, Akt, Autophagy, Autophagy-lysosomal pathway, Cell Cycle
UniProt ID	Q13501
GeneCards	SQSTM1
Human Protein Atlas	SQSTM1
LC3 (MAP1LC3B)	Primary autophagosomal marker that interacts with p62
NBR1	Neighbor of BRCA1 gene product; related selective autophagy receptor
TDP-43	RNA-binding protein whose aggregates accumulate with p62 in ALS
Alpha-synuclein	Parkinson's disease-related protein that accumulates with p62
mTOR	Nutrient-sensing kinase regulated by p62
Associated Diseases	AD, ADH, Aging, ALI, Als
Known Drugs/Compounds	ATC161, COENZYME Q10, DEXAMETHASONE, N-degrons, Palmostatin B, rapamycin
Interactions	4E-BP1, ABCA1, ABCD3, ABCG1, ACAT1, ACHE
SciDEX Hypotheses	Rutin enhances chaperone and autophagic clearance
KG Connections	4058 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING