concept

CRY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

126Connections

5Hypotheses

0Analyses

50Outgoing

41Incoming

10Experiments

0Debates

Summary

CRY is a concept in neurodegeneration research. Key relationships include: regulates, expressed in, activates. Associated with ALS, Als, Alzheimer. Connected to 84 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CRY
Key Genes/Proteins	ALZHEIMER, AMPK, AND, ARNT, BMAL1, CAMK2A
Related Diseases	Als, ALS, Alzheimer, Cancer, Cardiovascular

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CRY["CRY"]
    CRY -->|"inhibits"| CLOCK_BMAL1["CLOCK-BMAL1"]
    CRY -->|"involved_in"| Circadian_Rhythms["Circadian Rhythms"]
    CRY -->|"regulates"| Cellular_Metabolism["Cellular Metabolism"]
    CRY -->|"regulates"| Inflammation["Inflammation"]
    CRY -->|"regulates"| Als["Als"]
    CRY -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    CRY -->|"regulates"| Alzheimer["Alzheimer"]
    CRY -->|"regulates"| Parkinson["Parkinson"]
    CRY -->|"regulates"| Obesity["Obesity"]
    CRY -->|"regulates"| Ms["Ms"]
    PER["PER"] -->|"interacts"| CRY
    GENES["GENES"] -->|"expressed in"| CRY
    ARNT["ARNT"] -->|"expressed in"| CRY
    BMAL1["BMAL1"] -->|"expressed in"| CRY
    CLOCK["CLOCK"] -->|"expressed in"| CRY
    CAMK2A["CAMK2A"] -->|"expressed in"| CRY

Outgoing (85)

Target	Relation	Type	Str
METABOLIC HEALTH	regulates	entity	0.95
circadian rhythm	drives	process	0.95
Circadian Gene Expression	involved_in	process	0.90
CLOCK-BMAL1	inhibits	protein	0.90
Circadian Rhythm Regulation	regulates	process	0.90
Glioblastoma Growth	regulates	phenotype	0.90
Circadian Rhythms	involved_in	process	0.90
Cellular Metabolism	regulates	process	0.90
LIPID METABOLISM	regulates	entity	0.85
Insomnia	associated_with	disease	0.80
Metabolism	regulates	process	0.80
circadian rhythm	participates_in	process	0.80
Metabolic Syndrome	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	regulates	disease	0.65
ALS	activates	disease	0.65
circadian regulation	participates_in	pathway	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Depression	expressed_in	disease	0.65
Obesity	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Metabolic Syndrome	expressed_in	disease	0.65
Obesity	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
Diabetes	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
Glioblastoma	activates	disease	0.65
GENES	inhibits	gene	0.60
BMAL1	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
Oxidative Stress	regulates	pathway	0.60
Lipid Metabolism	regulates	pathway	0.60
Circadian Rhythm	regulates	pathway	0.60
Sleep-Wake	regulates	pathway	0.60
BMAL1	expressed_in	gene	0.60

Incoming (41)

Source	Relation	Type	Str
PER	interacts_with	gene	0.80
BMAL1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
GENES	activates	gene	0.60
CLOCK	associated_with	gene	0.60
ARNT	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
BMAL1	activates	gene	0.60
CLOCK	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
PER	associated_with	gene	0.60
PARKINSON	regulates	gene	0.60
PER	expressed_in	gene	0.60
BMAL1	interacts_with	gene	0.60
CLOCK	interacts_with	gene	0.60
CRY1	inhibits	gene	0.60
CANCER	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
REST	interacts_with	gene	0.60
GENES	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
PER	inhibits	gene	0.60
CAMK2A	expressed_in	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
GBM	activates	gene	0.60
PER	activates	gene	0.60
CIRCADIAN OUTPUT GENES	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
CLOCK GENE	expressed_in	gene	0.60
ARNT	regulates	gene	0.60
BMAL1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
AND	activates	gene	0.60
CANCER	activates	gene	0.60
CLOCK GENES	activates	gene	0.60
AMPK	causes	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SFPQ Paralog Displacement Triggers Cryptic Polyadenylation a	0.864	ALS	-
STMN2 Cryptic Exon Inclusion is the Earliest Loss-of-Functio	0.721	ALS	Causal Sequence of TDP-43 Nuclear Cleara
H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcr	0.610	neurodegeneration	Investigate mechanisms of epigenetic rep
TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gam	0.577	neurodegeneration	RNA binding protein dysregulation across
Cryptic Exon Silencing Restoration	0.531	neurodegeneration	RNA binding protein dysregulation across

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TDP-43 mutant mouse model cGAS/STING pathway analysis	validation	amyotrophic lateral sclerosis	0.900	0.00	TDP-43 mutant mice	proposed	N/A
TDP-43 mitochondrial invasion and DNA release via mPTP	exploratory	amyotrophic lateral sclerosis	0.900	0.00	cultured cells	proposed	N/A
TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons	exploratory	Amyotrophic Lateral Sclerosis	0.900	0.00	iPSC-derived motor neurons	proposed	N/A
cGAS/STING pathway validation in TDP-43 mutant mice	validation	Amyotrophic Lateral Sclerosis	0.850	0.00	TDP-43 mutant mice	proposed	N/A
cGAMP biomarker analysis in ALS patient spinal cord samples	exploratory	Amyotrophic Lateral Sclerosis	0.800	0.00	Human ALS patient spinal cord	proposed	N/A
TDP-43 pathology prevalence and distribution in AD cases	exploratory	Alzheimer's disease	0.800	0.00	human postmortem brain tissue	proposed	N/A
Cognitive impact of TDP-43 pathology in AD patients	clinical	Alzheimer's disease	0.700	0.00	human patients	completed	N/A
s:** - Temporal analysis showing mitochondrial defects precede other p	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
s:** - Single-cell RNA-seq to measure editing efficiency across differ	falsification	ALS	0.400	0.50	cell_line	proposed	$150,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Targets and Gene Therapy of ALS (Part 1). [PMID:40362304]	Shiryaeva O, Tolochko C, Alekseeva T, Dy	Int J Mol Sci	2025	1
The genetics of amyotrophic lateral sclerosis. [PMID:38967083]	Nijs M, Van Damme P	Curr Opin Neurol	2024	1
TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhi [PMID:39305312]	Torres P, Rico-Rios S, Ceron-Codorniu M,	Acta Neuropathol	2024	1
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. [PMID:35197628]	Brown AL, Wilkins OG, Keuss MJ, Kargbo-H	Nature	2022	1
Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP- [PMID:28405022]	Becker LA, Huang B, Bieri G, Ma R, Knowl	Nature	2017	1
Selective Silencing of TDP-43 P. G376D Mutation Reverses Key Amyotrophic Lateral [PMID:41897327]	Romano R, Ruotolo G, Perrone F, Tomasell	Biomolecules	2026	0
ALS-related proteinopathies: From TDP-43 to mitochondrial proteinopathies. [PMID:41570741]	Genin EC, Paquis-Flucklinger V	Current opinion in neurobiolog	2026	0
Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Protein [PMID:41900026]	Jamerlan A, Hulme J	Molecules (Basel, Switzerland)	2026	0
Axonal transport impairment as an upstream mechanism in amyotrophic lateral scle [PMID:41890591]	Gabbay U	Frontiers in neuroscience	2026	0
Role of Alpha-Synuclein in Frontotemporal Dementia: Narrative Review. [PMID:41827903]	Bougea A	Cells	2026	0
Versatile CRISPR-Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Bi [PMID:41671402]	["Shi M", "Ge W", "Li C", "Liu B", "Deng	Advanced science (Weinheim, Ba	2026	0
Splicing the narrative: alternative TARDBP splicing and its relation to neurodeg [PMID:41837283]	Miller MR, Dykstra M, Barmada S	The Journal of clinical invest	2026	0
Multi-modal dissection of cell-type specific TDP-43 pathology in the motor corte [PMID:41803120]	Ruf WP, Kühlwein JK, Meier L, Brockmann	Nature communications	2026	0
A neurotoxic cryptic peptide arising from TDP-43-dependent cryptic splicing of P [PMID:41720774]	["Yang M", "Wang Q", "Yan R", "Kang D",	Nature communications	2026	0
The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study [PMID:41883703]	Nassan M, Ayala I, Sloan J, Bonfitto A,	Neurology. Genetics	2026	0
Excitotoxicity in amyotrophic lateral sclerosis: a key pathogenic mechanism. [PMID:41890274]	Silva-Hucha S, Hernández RG, Baena-López	Brain communications	2026	0
PPAR-Delta Agonist Therapies Did Not Rescue Hallmark Disease Phenotypes in Two S [PMID:41751955]	["Luong D", "Niu C", "Kim E", "Tanji N",	International journal of molec	2026	0
Transcriptomic signature of frontotemporal lobar degeneration with TDP-43 type C [PMID:41789476]	["Rajicic A", "Mol M", "Melhem S", "Kisi	Brain : a journal of neurology	2026	0
Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progressi [PMID:41540015]	Ni N, Wang M, Yuan Z, Zhang L, Cai J, Du	International journal of oral	2026	0
TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sc [PMID:41838122]	Barone C, Wang R, Cooke S, Ng HP, Ferrei	Acta neuropathologica	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CRY in their description or question text

No additional research found

CRY

Understanding Entity Pages

Summary

Wiki Pages (6)

CRYAB Gene

αB-Crystallin (CRYAB)

CRY1 Gene

CRY2 Gene

CRY1 Protein

CRY2 Protein