concept

CLOCK GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLOCK GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CLOCK GENES
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, ALZHEIMER'S DISEASE NEUROPATHOLOGY, AND, APP, APP/PS1
Related Diseases	ALS, Alzheimer, Cancer, Cardiovascular
Related Pathways	Angiogenesis

Pathway Diagram

graph TD
    CLOCK_GENES["CLOCK GENES"]
    CLOCK_GENES -->|"regulates"| IMMUNE_CELLS["IMMUNE CELLS"]
    CLOCK_GENES -->|"regulates"| Tumor_Microenvironment["Tumor Microenvironment"]
    CLOCK_GENES -->|"regulates"| ALS["ALS"]
    CLOCK_GENES -->|"activates"| Glioblastoma["Glioblastoma"]
    CLOCK_GENES -->|"activates"| Cancer["Cancer"]
    CLOCK_GENES -->|"activates"| Tumor["Tumor"]
    CLOCK_GENES -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    CLOCK["CLOCK"] -->|"regulates"| CLOCK_GENES
    CLOCK_GENE["CLOCK GENE"] -->|"regulates"| CLOCK_GENES
    CCNA1["CCNA1"] -->|"regulates"| CLOCK_GENES
    CANCER["CANCER"] -->|"activates"| CLOCK_GENES
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| CLOCK_GENES
    SLEEP_WAKE_CYCLE["SLEEP-WAKE CYCLE"] -->|"regulates"| CLOCK_GENES
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| CLOCK_GENES

Outgoing (53)

Target	Relation	Type	Str
IMMUNE CELLS	regulates	entity	0.88
Tumor Microenvironment	regulates	process	0.85
CANCER-RELATED GENES	regulates	gene	0.85
metabolic pathways	regulates	pathway	0.85
ALS	regulates	disease	0.65
Tumor	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Inflammation	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
APP/PS1	expressed_in	gene	0.60
CIRCADIAN CLOCK GENES	expressed_in	gene	0.60
TAU	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
CIRCADIAN RHYTHM	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
Tau Phosphorylation	expressed_in	pathway	0.60
Circadian Rhythm	expressed_in	pathway	0.60
CIRCADIAN CLOCK GENES	contributes_to	gene	0.60
GABA	regulates	gene	0.60
Sleep-Wake Cycle	regulates	pathway	0.60
Synaptic Plasticity	regulates	pathway	0.60
Epigenetic	regulates	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
CRY1	expressed_in	gene	0.60
AND	regulates	gene	0.60
AND	activates	gene	0.60
GENES	associated_with	gene	0.60
CDK1	regulates	gene	0.60
Cell Cycle	regulates	pathway	0.60
Angiogenesis	regulates	pathway	0.60
GBM	activates	gene	0.60
BMAL1	activates	gene	0.60
CRY	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
CLOCK GENE	activates	gene	0.60
GENES	activates	gene	0.60
BMAL1	regulates	gene	0.60
GENES	regulates	gene	0.60
Circadian Rhythm	regulates	pathway	0.60
ARNT	regulates	gene	0.60
RNA	regulates	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
Circadian Rhythm	activates	pathway	0.60

Incoming (18)

Source	Relation	Type	Str
circadian rhythm disruption	downregulates	phenotype	0.85
SLEEP-WAKE CYCLE	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
CLOCK GENE	contributes_to	gene	0.60
ALZHEIMER'S DISEASE NEUROPATHOLOGY	expressed_in	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
APP	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
CLOCK	regulates	gene	0.60
CLOCK GENE	regulates	gene	0.60
CCNA1	regulates	gene	0.60
CANCER	activates	gene	0.60
CLOCK	activates	gene	0.60
CLOCK	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLOCK GENES in their description or question text

No additional research found