| Gene Symbol | CRYAB |
| Full Name | Crystallin Alpha B |
| Chromosome | 11q23.1 |
| Function | The CRYAB gene encodes αB-crystallin (also known as CRYAB or HspB5), a small heat shock protein (sHsp) that functions as a molecular chaperone |
| Primary Expression | many tissues including the brain, heart, and skeletal muscle, where it plays critical roles in protein quality control and cellular protection[@jin202 |
| Subcellular Localization | </td><td>Cytoplasm, nucleus, mitochondria, Z-discs</td></tr> |
| Pathways | MAPK signaling, Mapk, P38 Mapk, Proteostasis, lipid metabolism |
| UniProt ID | P02511 |
| NCBI Gene ID | 1410 |
| Ensembl ID | ENSG00000109846 |
| OMIM | 123590 |
| GeneCards | CRYAB |
| Human Protein Atlas | CRYAB |
| Temperature and stress | Heat stress promotes reassembly into larger oligomers |
| Phosphorylation | Ser19, Ser45 (PKC), Ser59 (MAPK) — modulates oligomeric state and chaperone activity |
| Associated Diseases | Als, Alzheimer, Cancer, Diabetes, Ms, neuroinflammation |
| Interactions | ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE |
| KG Connections | 148 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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