gene

C1Q

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1Q: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1531Connections

30Hypotheses

23Analyses

50Outgoing

50Incoming

18Experiments

20Debates

Summary

C1Q is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with AD, ALI, ALS. Connected to 856 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	C1QA
Full Name	Complement Component 1, Q Subunit A
Chromosome	1p36.33
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	The C1QA gene encodes the A-chain of complement component C1q.
Mechanism of Action	Complement cascade inhibitor or antibody-mediated neutralization
Primary Expression	Primarily expressed in myeloid cells (monocytes, macrophages, microglia); astrocytic expression detected in disease states
Subcellular Localization	synapses, dystrophic neurites, extracellular protein aggregates, and vascular interfaces. These features make C1QA a hig
Druggability	Low (0.41)
Clinical Stage	Phase II
Amino Acids	245 aa
Pathways	Complement, Complement system, Synaptic pruning, complement activation
UniProt ID	P02787
NCBI Gene ID	712
Ensembl ID	ENSG00000196954
OMIM	120550
GeneCards	C1QA
Human Protein Atlas	C1QA
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	ANX005
Interactions	AIF1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXIETY
SciDEX Target	View Target Profile (7 clinical trials)
SciDEX Hypotheses	Complement C1q Mimetic Decoy Therapy Complement C1QA Spatial Gradient in Cortical Layer Complement C1q Subtype Switching (+3 more)
KG Connections	704 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: C1Q — AlphaFold P02745 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    C1Q["C1Q"] -->|"associated"| neurodegeneration["neurodegeneration"]
    C1Q["C1Q"] -->|"interacts"| C3["C3"]
    C1Q["C1Q"] -->|"co discussed"| NAMPT["NAMPT"]
    C1Q["C1Q"] -->|"co discussed"| GPX4["GPX4"]
    C1Q["C1Q"] -->|"co discussed"| PLA2G6["PLA2G6"]
    C1Q["C1Q"] -->|"co discussed"| MMP2["MMP2"]
    C3_1["C3"] -->|"interacts"| C1Q["C1Q"]
    MMP9["MMP9"] -->|"co discussed"| C1Q["C1Q"]
    SLC7A11["SLC7A11"] -->|"co discussed"| C1Q["C1Q"]
    AQP4["AQP4"] -->|"co discussed"| C1Q["C1Q"]
    style C1Q fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1090)

Target	Relation	Type	Str
PHAGOCYTOSIS	activates	phenotype	1.00
CR3	signals_through	receptor	1.00
phagocytosis	activates	phenotype	1.00
Als	associated_with	disease	1.00
MICROGLIA	activates	cell_type	1.00
Complement	activates	pathway	1.00
Alzheimer's Disease	mediates	disease	0.95
Atherosclerosis	associated_with	disease	0.95
A1 Reactive Astrocytes	associated_with	phenotype	0.95
Alzheimer	activates	disease	0.95
Tumor	associated_with	disease	0.95
Inflammation	activates	disease	0.95
Tumor-Associated Macrophages	expressed_in	cell_type	0.95
Synapse Loss	mediates	phenotype	0.95
ATHEROSCLEROSIS	associated_with	entity	0.95
A1 Astrocytes	associated_with	phenotype	0.95
C3-Cr3 Signaling Pathway	activates	pathway	0.95
Reactive Astrocytes	activates	cell_type	0.95
Trained Immunity	modulates	process	0.95
Microglial Phagocytosis	mediates	process	0.95
Alzheimer'S Disease	involved_in	disease	0.92
Complement system	associated_with	pathway	0.90
Classical complement pathway	activates	pathway	0.90
Microglial Phagocytosis Of Synapses	regulates	process	0.90
Human Atherosclerotic Plaques	associated_with	phenotype	0.90
DOR	binds	protein	0.90
Alectinib	binds	drug	0.90
Myeloid Cell Metabolism	associated_with	process	0.90
Microglial Synapse Engulfment	activates	process	0.90
synaptic dysfunction	causes	phenotype	0.90
A1 reactive astrocytes	activates	cell_type	0.90
immunosuppression	causes	phenotype	0.90
classical complement cascade	activates	pathway	0.90
NEUROINFLAMMATION	mediates	entity	0.90
Synapse Elimination	mediates	process	0.90
Microglial Synapse Engulfment	mediates	process	0.90
Classical Complement Cascade	activates	pathway	0.90
Synapse Loss	associated_with	phenotype	0.90
ISCHEMIC STROKE	associated_with	entity	0.90
complement_cascade	participates_in	pathway	0.90
β-Amyloid Oligomer Toxicity	associated_with	mechanism	0.90
Complement	inhibits	pathway	0.90
Phagocytosis	activates	pathway	0.90
Beta-Amyloid Oligomers	interacts_with	compound	0.88
Inflammatory Reactivity	inhibits	phenotype	0.88
SYNAPSE_ELIMINATION	regulates	phenotype	0.87
Large Artery Atherosclerosis	biomarker_for	disease	0.85
NEUROCOGNITIVE DYSFUNCTION	contributes_to	entity	0.85
Als	therapeutic_target	disease	0.85
Atherosclerotic Plaques	associated_with	structure	0.85

Incoming (441)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
COMPLEMENT	activates	gene	1.00
MICROGLIA	associated_with	gene	1.00
NPTX2	binds	protein	0.95
h-58e4635a	targets	hypothesis	0.90
33628204	interact with	paper	0.90
h-89500d80	targets	hypothesis	0.90
TYROBP deficiency	inhibits	phenotype	0.90
SPP1	upregulates	entity	0.90
NEURODEGENERATION	associated_with	gene	0.90
TYROBP	regulates	protein	0.85
β-Amyloid Oligomers	interacts_with	compound	0.85
MICROGLIA	inhibits	gene	0.82
AMYLOID	associated_with	gene	0.82
CD2AP	correlates_with	protein	0.80
MICROGLIA	expressed_in	gene	0.80
DOR	binds	gene	0.80
ABETA	upregulates	protein	0.80
SDA-2026-04-01-gap-013	targets	analysis	0.80
microglia	produces	cell_type	0.80
OCULAR HYPERTENSION	upregulates	biological_process	0.80
STAT6-MafB pathway	contributes_to	pathway	0.80
COMPLEMENT	inhibits	gene	0.80
ALZHEIMER	activates	gene	0.80
COMPLEMENT	regulates	gene	0.80
Astrocytes	associated_with	cell_type	0.75
Microglia	associated_with	cell_type	0.75
MICROGLIA	activates	cell_type	0.74
ASTROCYTES	associated_with	gene	0.74
NPTX2	interacts_with	protein	0.72
APOE	interacts_with	protein	0.70
ALZHEIMER	regulates	gene	0.70
C1QA	activates	gene	0.70
PDE4B	regulates	gene	0.70
NEURODEGENERATIVE DISEASES	causes	gene	0.70
NEURODEGENERATIVE DISEASES	activates	gene	0.70
ocular hypertension	activates	disease	0.70
COMPLEMENT	biomarker_for	gene	0.70
COMPLEMENT	associated_with	gene	0.70
TAU	activates	gene	0.70
retinal ischemia/reperfusion injury	activates	process	0.70
CYTOKINES	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
oxidized lipids	activates	process	0.70
NEURODEGENERATIVE DISORDERS	activates	gene	0.70
COMPLEMENT	interacts_with	gene	0.70
APOE	associated_with	gene	0.70
periodontal infection	activates	disease	0.70
HMGB1	enhances	gene	0.70
AMYLOID	activates	gene	0.70

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective blockade of classical-pathway activation downstrea	0.750	neurodegeneration	Does C1q function differ based on subcel
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.747	neurodegeneration	Are interneuron oscillation deficits com
TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina	0.724	neurodegeneration	How do the seven novel ALS genes functio
Excessive C1q/C3/CR3 complement cascade activation initiates	0.720	neurodegeneration	Synaptic pruning by microglia in neurode
Complement C1q Mimetic Decoy Therapy	0.695	neurodegeneration	Synaptic pruning by microglia in early A

C1q-TREM2 Competition for Phosphatidylserine as Pruning Chec	0.680	Alzheimer's disease	-
Complement C1QA Spatial Gradient in Cortical Layers	0.678	Alzheimer's Disease	SEA-AD Gene Expression Profiling — Allen
Microglial TREM2 state determines whether C1q-tagged substra	0.670	neurodegeneration	Does C1q function differ based on subcel
Complement C1q Subtype Switching	0.665	neurodegeneration	4R-tau strain-specific spreading pattern
Complement C1QA Inhibition Synergizes with PV Interneuron Mo	0.659	neurodegeneration	What molecular mechanisms underlie the d
C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macropha	0.640	neuroinflammation	What are the specific molecular mechanis
C1q has spatially distinct functions, with synapse-bound C1q	0.630	neurodegeneration	Does C1q function differ based on subcel
C1Q-Induced Foam Cell Formation via Scavenger Receptor Upreg	0.620	neuroinflammation	What are the specific molecular mechanis
C1q effector output is determined more by binding partner id	0.610	neurodegeneration	Does C1q function differ based on subcel
C1Q-Mediated Defective Efferocytosis Driving Necrotic Core E	0.600	neuroinflammation	What are the specific molecular mechanis
Selective C1q-CRP vs. C1q-IgG Axis Inhibition	0.599	neuroinflammation	How does Alectinib, a kinase inhibitor,
TREM2-C1Q Competitive Binding to Prevent Complement-Mediated	0.591	neurodegeneration	Do β-amyloid plaques and neurofibrillary
APOE isoform modifies the C1q binding landscape, biasing C1q	0.590	neurodegeneration	Does C1q function differ based on subcel
Direct NF-κB Transcriptional Regulation of C1q Genes in Micr	0.570	neuroinflammation	How does sevoflurane-induced NF-κB activ
Complement C1q Suppression as Mechanism Linking Exercise Pla	0.560	neurodegeneration	What are the specific circulating factor
C1q Binding to Specific Synaptic Proteomes via Neurexin/Neur	0.550	synaptic biology	What determines the selectivity of compl
NFκB/C1Q SASP Modulation for Synaptic Protection	0.534	neurodegeneration	View
C1q shows synapse-class-specific roles, with inhibitory vers	0.530	neurodegeneration	Does C1q function differ based on subcel
C1Q-Angiogenic Axis Promoting Plaque Neovascularization	0.530	neuroinflammation	What are the specific molecular mechanis
Tripartite Synapse Cell Type-Nonautonomous Crosstalk: Coordi	0.510	neurodegeneration	Cell type vulnerability debate in Alzhei
NETosis Amplification by C1Q in Plaque Neutrophils	0.500	neuroinflammation	What are the specific molecular mechanis
Alectinib-C1q Complex Hijacks TREM2's Synaptic Protective Bi	0.500	neuroinflammation	How does Alectinib, a kinase inhibitor,
C1q-Mediated Delivery of miR-33 Antisense Oligonucleotides f	0.489	molecular biology	Is APOE4's reduced lipid binding pathoge
C1Q-Glia Cross-Talk in Vascular Dementia Pathogenesis	0.470	neuroinflammation	What are the specific molecular mechanis
Kinase Inhibitor-C1q Structural Convergence for Bifunctional	0.458	neuroinflammation	How does Alectinib, a kinase inhibitor,

Mentioning Analyses (23)

Scientific analyses that reference this entity

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.616

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

neurodegeneration | 2026-04-10 | 0 hypotheses

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

neurodegeneration | 2026-04-10 | 0 hypotheses

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (18)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Bidirectional Mendelian randomization analysis of C1Q and ischemic str	exploratory	Ischemic stroke, Atheroscleros	0.900	0.00	Human genetic association data	proposed	N/A
Bidirectional Mendelian randomization analysis of C1Q and ischemic str	exploratory	Ischemic stroke (large artery	0.900	0.00	human genetic data	proposed	N/A
Single-cell RNA sequencing analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	0.00	Human atherosclerotic plaque s	proposed	N/A
Endothelium-specific TBK1 knockdown in atherosclerosis model	validation	atherosclerosis	0.900	0.00	endothelium-specific TBK1 knoc	proposed	N/A
TBK1-PAK1IP1-PAK1 signaling pathway analysis	exploratory	atherosclerosis	0.900	0.00	endothelial cells	proposed	N/A
C1q neutralization experiment	validation	perioperative neurocognitive d	0.900	0.00	rats	proposed	N/A
scRNA-seq analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	0.00	human atherosclerotic plaque s	proposed	N/A
Sevoflurane-induced neurotoxicity (SIN) model in rats	validation	perioperative neurocognitive d	0.900	0.00	rats	proposed	N/A
Machine learning-based identification of C1Q hub genes	exploratory	Atherosclerosis	0.900	0.00	Human bulk RNA sequencing data	proposed	N/A
Gene expression validation in apoE-/- mice	validation	Atherosclerosis	0.850	0.00	apoE-/- mice	proposed	N/A
ox-LDL treatment of RAW264.7 macrophages	exploratory	Atherosclerosis	0.850	0.00	RAW264.7 macrophages	proposed	N/A
GSK8612 treatment in atherosclerosis model	validation	atherosclerosis	0.800	0.00	atherosclerosis mouse model	proposed	N/A
LC-MS/Western blot analysis of TBK1 in atherosclerotic arteries	exploratory	atherosclerosis	0.800	0.00	mouse and human arteries with	proposed	N/A
Validation of hub genes in ox-LDL treated RAW264.7 macrophages	exploratory	Atherosclerosis	0.800	0.00	RAW264.7 macrophages	proposed	N/A
Validation of hub genes in apoE-/- atherosclerotic mice	validation	Atherosclerosis	0.800	0.00	apoE-/- mice	proposed	N/A
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Synaptic pruning by microglia in ea	falsification	Alzheimer's Disease	0.400	0.50	mouse	proposed	$200,000
Experiment: Autoimmune Hypothesis Testing in AD	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274]	Xu F, Han L, Wang Y, Deng D, Ding Y, Zha	BMC Med	2023	2
Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024]	De Schepper S, Ge JZ, Sierksma A, Crowle	Nat Neurosci	2023	2
An integrative analysis of single-cell and bulk transcriptome and bidirectional [PMID:38179058]	Cui HK, Tang CJ, Gao Y, Li ZA, Zhang J,	Front Immunol	2023	2
Early complement genes are associated with visual system degeneration in multipl [PMID:31289819]	Fitzgerald KC, Kim K, Smith MD, Aston SA	Brain	2019	1
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	Geroscience	2026	0
Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediat [PMID:40660474]	Li J, Yang Y, Ge Y, Zhang X, Liu H et al	Autophagy	2026	0
Aberrant STING signalling promotes endothelial dysfunction and neurovascular inj [PMID:41419617]	Qin X, Chen S, Sun Y, Ma Z, Niu C et al.	Diabetologia	2026	0
TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons. [PMID:41485128]	Mordes DA, Smeyers J	Autophagy	2026	0
Dynamic regulation of TBK1 lactylation shapes antiviral immune responses. [PMID:41530535]	Xie Y, Zhang Y, Peng W, Zhang L, Hu Z et	Cell Mol Immunol	2026	0
RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodege [PMID:41603250]	Naumann M, Wierschin TM, Kretschmer S, D	Adv Sci (Weinh)	2026	0
Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross-Species Transcr [PMID:41664952]	Arif M, Hasan MN, Nozaki N, Ide Y, Akiya	Mol Carcinog	2026	0
BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic [PMID:41710977]	Liu Q, Zhang X, Wang L, Chen H, Wang G e	Brain	2026	0
Systematic Review: Porphyromonas gingivalis Outer Membrane Vesicles From Pathoge [PMID:41980468]	Li Z, Luo C, Wen P, Zou T, Jin Z et al.	Int Dent J	2026	0
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	GeroScience	2026	0
Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: se [PMID:41853292]	Zhai X, Lin X, Zhang L, Ren Y, Miao H, M	Frontiers in immunology	2026	0
Proteomic Signature in Men with Central Serous Chorioretinopathy. [PMID:41641862]	Chambon C, Picard E, Zola M, Aichedo S,	Journal of proteome research	2026	0
Machine Learning and Blood-Targeted Proteomics Enable Early Prediction and Etiol [PMID:41683823]	Starodubtseva N, Tokareva A, Kononikhin	International journal of molec	2026	0
TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons. [PMID:41485128]	Mordes DA, Smeyers J	Autophagy	2026	0
BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic [PMID:41710977]	Liu Q, Zhang X, Wang L, Chen H, Wang G,	Brain : a journal of neurology	2026	0
RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodege [PMID:41603250]	Naumann M, Wierschin TM, Kretschmer S, D	Advanced science (Weinheim, Ba	2026	0

Debates (20)

Multi-agent debates referencing this entity

What is the role of microglial synaptic pruning in Alzheimer's disease and other

closed · Rounds: 4 · Score: 0.68 · 2026-04-22

While the study establishes C1QA and C1QC as diagnostic biomarkers and confirms

closed · Rounds: 4 · Score: 0.71 · 2026-04-21

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

closed · Rounds: 0 · Score: 0.66 · 2026-04-21

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

closed · Rounds: 0 · Score: 0.64 · 2026-04-21

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The abstract explicitly questions whether AD's hallmark pathologies induce choli

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

The abstract reveals an unexpected contradiction where PRKN activation, normally

closed · Rounds: 4 · Score: 0.91 · 2026-04-15

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

closed · Rounds: 4 · Score: 0.69 · 2026-04-12

Related Research

Hypotheses and analyses mentioning C1Q in their description or question text

C1Q

Understanding Entity Pages

Summary

Wiki Pages (7)

C1QA Gene — Complement Component 1q A Chain

C1QB Protein — Complement Component 1 Q

C1QA Gene

C1Q Protein (Complement Component 1q)

C1QB — Complement Component 1Q Beta

C1QC Protein

C1QC

Pathway Diagram

Outgoing (1090)

Incoming (441)

Targeting Hypotheses (30)

Mentioning Analyses (23)

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

What are the specific molecular mechanisms by which C1Q components drive atheros

Epigenetic reprogramming in aging neurons

Tau propagation mechanisms and therapeutic interception points

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Synaptic pruning by microglia in neurodegeneration

Epigenetic clocks and biological aging in neurodegeneration

Mitochondrial transfer between astrocytes and neurons

RNA binding protein dysregulation across ALS FTD and AD

Synaptic pruning by microglia in early AD

Senolytic therapy for age-related neurodegeneration

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Blood-brain barrier transport mechanisms for antibody therapeutics

Mechanistic role of APOE in neurodegeneration

Experiments (18)

Related Papers (20)

Debates (20)

What is the role of microglial synaptic pruning in Alzheimer's disease and other

While the study establishes C1QA and C1QC as diagnostic biomarkers and confirms

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

The abstract explicitly questions whether AD's hallmark pathologies induce choli

The abstract reveals an unexpected contradiction where PRKN activation, normally

Investigate prion-like spreading of tau pathology through connected brain region

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

Related Research

Complement C1QA Spatial Gradient in Cortical Layers

Microglial TREM2 state determines whether C1q-tagged substrates are cleared adap

Complement C1q Subtype Switching

Complement C1QA Inhibition Synergizes with PV Interneuron Modulation

C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macrophages

C1q has spatially distinct functions, with synapse-bound C1q primarily nucleatin

C1Q-Induced Foam Cell Formation via Scavenger Receptor Upregulation

C1q effector output is determined more by binding partner identity than by subce

C1Q-Mediated Defective Efferocytosis Driving Necrotic Core Expansion

Selective C1q-CRP vs. C1q-IgG Axis Inhibition

TREM2-C1Q Competitive Binding to Prevent Complement-Mediated Cholinergic Synapse

APOE isoform modifies the C1q binding landscape, biasing C1q toward inflammatory

Direct NF-κB Transcriptional Regulation of C1q Genes in Microglia

Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuro