| Gene Symbol | C1Q |
| Aliases | C1QPROTEIN |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | Complement cascade inhibitor or antibody-mediated neutralization |
| Mechanism of Action | Complement cascade inhibitor or antibody-mediated neutralization |
| Primary Expression | Primarily expressed in myeloid cells (monocytes, macrophages, microglia); astrocytic expression detected in disease states |
| Druggability | Low (0.36) |
| Clinical Stage | Approved |
| Molecular Weight | 26 kDa |
| Pathways | Chaperone, Complement, Differentiation, Endocytosis, Epigenetic |
| UniProt ID | P02745 |
| NCBI Gene ID | 712 |
| Ensembl ID | ENSG00000173372 |
| GeneCards | C1Q |
| Human Protein Atlas | C1Q |
| Associated Diseases | A1 Astrocytes, A1 Reactive Astrocytes, AD, Aging, ALI |
| Known Drugs/Compounds | Alectinib, Beta-Amyloid Oligomers, LPS, rapamycin, RAPAMYCIN, β-amyloid Oligomers |
| Interactions | ACOX1, ACSL4, Adiponectin, ADIPOQ, ADORA2A, AGING |
| SciDEX Target | View Target Profile (4 clinical trials) |
| SciDEX Hypotheses | Complement C1q-Mediated Synaptic Pruning Drives Ea NFκB/C1Q SASP Modulation for Synaptic Protection Tripartite Synapse Cell Type-Nonautonomous Crossta (+9 more) |
| KG Connections | 1502 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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