concept

T CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about T CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

914Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

T CELLS is a concept in neurodegeneration research. Key relationships include: co discussed, activates, inhibits. Associated with CANCER, ISCHEMIA, LYMPHOMA. Connected to 126 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	T CELLS
Key Genes/Proteins	AIM2, AKT, ALPHA-SYNUCLEIN, AMPK, ANXA1
Related Diseases	ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE

Pathway Diagram

graph TD
    T_CELLS["T CELLS"]
    T_CELLS -->|"contributes to"| Salivary_Gland_Damage["Salivary Gland Damage"]
    T_CELLS -->|"regulates"| Amyloid_plaque_accumulation["Amyloid plaque accumulation"]
    T_CELLS -->|"transports"| TUMOR["TUMOR"]
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| T_CELLS
    T_CELL["T CELL"] -->|"expressed in"| T_CELLS
    AQP4["AQP4"] -->|"activates"| T_CELLS
    B_CELL["B CELL"] -->|"activates"| T_CELLS
    PARP1["PARP1"] -->|"inhibits"| T_CELLS
    CELL_DEATH["CELL DEATH"] -->|"inhibits"| T_CELLS
    AUTOPHAGY["AUTOPHAGY"] -->|"transports"| T_CELLS
    CANCER["CANCER"] -->|"transports"| T_CELLS
    DNA_DAMAGE["DNA DAMAGE"] -->|"transports"| T_CELLS
    INFLAMMATION["INFLAMMATION"] -->|"expressed in"| T_CELLS
    FERROPTOSIS["FERROPTOSIS"] -->|"causes"| T_CELLS

Outgoing (146)

Target	Relation	Type	Str
Tumor Microenvironment	involved_in	process	0.90
Salivary Gland Damage	contributes_to	phenotype	0.90
NEUROINFLAMMATION	contributes_to	process	0.85
Upper Airway Inflammation	associated_with	phenotype	0.85
Inflammatory Factors	upregulates	process	0.85
Psoriasis	causes	disease	0.85
PARKINSON'S DISEASE	biomarker_for	disease	0.80
Inflammatory Factors	upregulates	protein	0.80
Cytotoxicity	downregulates	process	0.80
Central Nervous System	involved_in	mechanism	0.80
ALS	infiltrates	disease	0.80
Inclusion Body Myositis	involved_in	disease	0.80
Amyloid plaque accumulation	regulates	process	0.70
NEURODEGENERATION	protects_against	phenotype	0.70
amyotrophic lateral sclerosis	infiltrates	disease	0.70
Parkinson's disease	associated_with	disease	0.70
neuroinflammation	activates	disease	0.70
TUMOR	increases	disease	0.65
BACE1	regulates	gene	0.65
DEMYELINATION	protects_against	phenotype	0.65
TDP-43	activates	gene	0.65
CANCER	causes	disease	0.65
PSORIASIS	treats	disease	0.65
CANCER	associated_with	disease	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
MTOR	treats	gene	0.65
CELL DEATH	targets	phenotype	0.65
CYTOKINES	causes	phenotype	0.65
OLIGODENDROCYTE	activates	cell_type	0.65
DENTATE GYRUS	activates	brain_region	0.65
PECAM1	activates	gene	0.65
PECAM1	regulates	gene	0.65
TUMOR	interacts_with	disease	0.65
TUMOR	targets	disease	0.65
TUMOR	causes	disease	0.65
TUMOR MICROENVIRONMENT	interacts_with	phenotype	0.65
TUMOR MICROENVIRONMENT	produces	phenotype	0.65
TUMOR MICROENVIRONMENT	treats	phenotype	0.65
ASTHMA	causes	disease	0.65
CD33	produces	gene	0.65
GLIOBLASTOMA	causes	disease	0.65
CYCLOPHOSPHAMIDE	treats	drug	0.65
CYTOKINES	regulates	phenotype	0.65
CYTOKINES	inhibits	phenotype	0.65
TUMOR	inhibits	disease	0.60
necroptosis	inhibits	process	0.60
Parkinson's disease	expressed_in	disease	0.60
multiple sclerosis	causes	disease	0.60
TUMOR	contributes_to	disease	0.60
TUMOR	promotes	disease	0.60

Incoming (768)

Source	Relation	Type	Str
CD4	interacts_with	gene	0.95
CD8	interacts_with	gene	0.95
RNA	expressed_in	gene	0.90
PD-L1	inhibits	protein	0.90
Synthetic Notch Receptors	activates	receptor	0.90
CD33	expressed_in	gene	0.90
GBM	expressed_in	gene	0.90
DNA	expressed_in	gene	0.90
CD4	associated_with	gene	0.90
CD8	associated_with	gene	0.90
TCR	expressed_in	gene	0.90
CD4	regulates	gene	0.80
CD8	activates	gene	0.80
CD4	expressed_in	gene	0.80
CD8	expressed_in	gene	0.80
TNF	expressed_in	gene	0.80
multiple sclerosis	affects	disease	0.80
spinal muscular atrophy	affects	disease	0.80
INFLAMMATION	activates	process	0.80
B CELLS	interacts_with	cell_type	0.80
NAD	expressed_in	gene	0.80
CD8	activates	gene	0.80
NEOANTIGENS	activates	entity	0.80
APOE	associated_with	gene	0.80
Autophagy	modulates	process	0.80
Autophagy	regulates	process	0.80
neurodegeneration	affects	disease	0.80
IFN	expressed_in	gene	0.80
GBM	regulates	gene	0.70
unfolded protein response	active_in	pathway	0.70
TFEB	expressed_in	gene	0.70
glioblastoma	affects	disease	0.70
CXCL10	activates	gene	0.70
neuroinflammation	affects	disease	0.70
TNF	activates	gene	0.70
CD4	activates	gene	0.70
TNF	regulates	gene	0.70
AMPK	expressed_in	gene	0.70
CCL4	expressed_in	gene	0.70
ATP	expressed_in	gene	0.70
GDNF	expressed_in	gene	0.70
ROS	expressed_in	gene	0.70
CD8	biomarker_for	gene	0.70
TP53	activates	gene	0.70
CD8	inhibits	gene	0.70
Parkinson's disease	affects	disease	0.70
IFN	activates	gene	0.70
NOTCH1	expressed_in	gene	0.70
NAD	activates	gene	0.70
IFN	inhibits	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Exosomal SNCA Propagation from Lysosome-Compromised Neurons	0.777	neurodegeneration	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning T CELLS in their description or question text

No additional research found