concept

NEUROFIBRILLARY TANGLES

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NEUROFIBRILLARY TANGLES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

185Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NEUROFIBRILLARY TANGLES
Key Genes/Proteins	Alpha-Synuclein, ALPHA-SYNUCLEIN, ALZHEIMER, AMYLOID, AMYLOID-BETA, AMYLOID-Β PLAQUES
Related Diseases	Alzheimer Disease, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Neurofibrillary Tangles

mechanism · 3191 words

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Pathway Diagram

graph TD
    NEUROFIBRILLARY_TANGLES["NEUROFIBRILLARY TANGLES"]
    NEUROFIBRILLARY_TANGLES -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    NEUROFIBRILLARY_TANGLES -->|"interacts"| TAU["TAU"]
    NEUROFIBRILLARY_TANGLES -->|"interacts"| NEURON["NEURON"]
    NEUROFIBRILLARY_TANGLES -->|"expressed in"| Entorhinal_Cortex["Entorhinal Cortex"]
    NEUROFIBRILLARY_TANGLES -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    TAU -->|"component_of"| NEUROFIBRILLARY_TANGLES
    HYPERPHOSPHORYLATED_TAU["HYPERPHOSPHORYLATED TAU"] -->|"causes"| NEUROFIBRILLARY_TANGLES
    AGGREGATED_TAU["AGGREGATED TAU"] -->|"component_of"| NEUROFIBRILLARY_TANGLES
    AMYLOID["AMYLOID"] -->|"interacts"| NEUROFIBRILLARY_TANGLES
    Phosphorylated_Tau["Phosphorylated Tau"] -->|"causes"| NEUROFIBRILLARY_TANGLES
    Tau_Phosphorylation["Tau Phosphorylation"] -->|"contributes to"| NEUROFIBRILLARY_TANGLES
    Alzheimer_s_Disease -->|"causes"| NEUROFIBRILLARY_TANGLES

Outgoing (52)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.98
ALZHEIMER'S DISEASE	biomarker_for	disease	0.95
Alzheimer'S Disease	biomarker_for	disease	0.95
Alzheimer Disease	associated_with	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.95
TAU	interacts_with	protein	0.95
NEURON	interacts_with	cell_type	0.95
Gray Matter	associated_with	organelle	0.93
Entorhinal Cortex	expressed_in	cell_type	0.90
pS65-Ub	associated_with	biomarker	0.88
Neurodegeneration	causes	process	0.85
TAU	contributes_to	protein	0.80
AMYLOID-BETA	exacerbates	protein	0.70
Alzheimer's disease	associated_with	disease	0.70
Alzheimer's disease	biomarker_for	disease	0.70
cognitive decline	causes	process	0.70
NEURODEGENERATION	regulates	disease	0.65
SYNAPTIC PLASTICITY	causes	phenotype	0.65
COGNITIVE DECLINE	interacts_with	phenotype	0.65
NEURONS	causes	cell_type	0.65
NEUROINFLAMMATION	associated_with	process	0.65
NEUROINFLAMMATION	stabilizes	phenotype	0.65
TAU	activates	protein	0.65
ALZHEIMER'S DISEASE	expressed_in	disease	0.55
ENTORHINAL CORTEX	associated_with	concept	0.50
CEREBRAL CORTEX	associated_with	brain_region	0.50
SUBSTANTIA NIGRA	associated_with	brain_region	0.50
COMPLEMENT CASCADE	associated_with	pathway	0.50
MTOR PATHWAY	associated_with	pathway	0.50
NLRP3 INFLAMMASOME	associated_with	pathway	0.50
TAU	phosphorylates	protein	0.50
NEURON	expressed_in	cell_type	0.50
THALAMUS	associated_with	brain_region	0.45
TEMPORAL LOBE	associated_with	brain_region	0.45
HYPOTHALAMUS	associated_with	brain_region	0.45
LITHIUM	associated_with	drug	0.45
SPINAL CORD	associated_with	brain_region	0.45
RAPAMYCIN	associated_with	drug	0.45
BRAINSTEM	associated_with	brain_region	0.45
BDNF/TRKB SIGNALING	associated_with	pathway	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
TAU	processes	protein	0.35
ROS	activates	protein	0.35
NEURON	regulates	cell_type	0.35
NEURON	causes	cell_type	0.35
PROTEIN AGGREGATION	contributes_to	process	0.35
NEURON	activates	cell_type	0.35
NEUROINFLAMMATION	causes	process	0.35
TAU	expressed_in	protein	0.35
TAU	biomarker_for	protein	0.35

Incoming (133)

Source	Relation	Type	Str
AGGREGATED TAU	component_of	protein	0.95
Tau Hyperphosphorylation	causes	process	0.95
Amyloid-Β	causes	protein	0.95
HYPERPHOSPHORYLATED TAU	causes	protein	0.95
Tau	contributes_to	protein	0.95
Tau	involved_in	protein	0.95
TAU	promotes	protein	0.95
Acetylated Tau Aggregates	contributes_to	biomarker	0.95
TAU	component_of	protein	0.95
AMYLOID	interacts_with	protein	0.95
Tau Protein	causes	protein	0.95
Phosphorylated Tau	causes	protein	0.90
Senescent Cells	contributes_to	cell_type	0.90
Neuronal Cholesterol	promotes	biomarker	0.90
41090735	are hallmark of	paper	0.90
TAU	causes	protein	0.90
30394574	occurs in brain regions with high	paper	0.90
41090735	promote aggregation into	paper	0.90
MAPT	involved_in	gene	0.90
TAU	part_of	gene	0.90
tau	drives	protein	0.90
GFAP	correlates_with	protein	0.85
Tau-Directed Therapies	suppresses	drug	0.85
Ufmylation Cascade	associated_with	pathway	0.85
Alzheimer's Disease	causes	disease	0.85
Tau Phosphorylation	contributes_to	process	0.85
Tdp-43 Pathology	associated_with	biomarker	0.85
oxidative stress	elevates	process	0.80
AMYLOID	associated_with	protein	0.80
SQSTM1	co_expressed_with	protein	0.80
tau-directed therapies	inhibits	pathway	0.80
TDP-43	associated_with	protein	0.75
Alzheimer's disease	associated_with	disease	0.70
tau protein	promotes	protein	0.70
CDK5	causes	gene	0.65
DEMENTIA	associated_with	disease	0.65
AMYLOID	activates	protein	0.65
ROS	produces	phenotype	0.65
TAU	inhibits	protein	0.65
TAU	activates	protein	0.65
ROS	regulates	phenotype	0.65
GFAP	interacts_with	gene	0.65
INFLAMMATION	causes	phenotype	0.65
INFLAMMATION	phosphorylates	phenotype	0.65
TAU	produces	protein	0.60
tau	causes	protein	0.60
CASS4	involved_in	protein	0.60
DMPK	associated_with	gene	0.60
TAU	participates_in	protein	0.55
Neuroinflammation	associated_with	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEUROFIBRILLARY TANGLES in their description or question text

No additional research found